Comparison Between Signature Cytokines of Nasal Tissues in Subtypes of Chronic Rhinosinusitis

被引:54
作者
Kim, Dong-Kyu [1 ,2 ,3 ]
Eun, Kyoung Mi [4 ]
Kim, Min-Kyung [4 ]
Cho, Deuktae [4 ]
Han, Sun A. [4 ]
Han, Sang-Yoon [4 ]
Seo, Yuju [4 ]
Lee, Dong-Han [4 ]
Cho, Seong Ho [5 ]
Kim, Dae Woo [3 ,4 ]
机构
[1] Hallym Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Chuncheon Sacred Heart Hosp, Chunchon, South Korea
[2] Hallym Univ, Coll Med, Inst New Frontier Res, Chunchon, South Korea
[3] Clin Mucosal Immunol Study Grp, Seoul, South Korea
[4] Seoul Natl Univ, Seoul Metropolitan Govt, Dept Otorhinolaryngol Head & Neck Surg, Boramae Med Ctr,Coll Med, 20 Boramae Ro 5-Gil, Seoul 07061, South Korea
[5] Univ S Florida, Div Allergy Immunol, Dept Internal Med, Morsani Coll Med, Tampa, FL USA
基金
新加坡国家研究基金会;
关键词
Cytokines; rhinitis; sinusitis; nasal polyp; INFLAMMATION; POLYPS; CELLS; FEATURES; SURGERY;
D O I
10.4168/aair.2019.11.2.201
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Purpose: Endotype in chronic rhinosinusitis (CRS) has been established in the last decade. However, the exact immunologic profile of CRS still has controversy because it has a considerable immunologic heterogeneity. Therefore, we investigated various inflammatory mediators according to different nasal tissues in chronic rhinosinusitis and compared them within the same subject. Methods: We collected uncinate process mucosa (UP) and nasal polyp (NP) tissues from controls, CRS without NP (CRSsNP) and CRS with NP (CRSwNP). Expression levels of 28 inflammatory mediators including T helper (Th) 1, Th2, Th17, proinflammatory cytokines and remodeling markers were determined by multiplex immunoassay and were analyzed using paired tests as well as principal component analysis (PCA) to investigate endotype in each subtype of CRS. Results: Signature inflammatory mediators are interleukin (IL)-5, C-C motif chemokine ligand (CCL)-24, monocyte chemoattractant protein (MCP)-4, and vascular cell adhesion molecule (VCAM)-1 in eosinophilic NP, whereas IL-17A, IL-1 beta, and matrix metallopeptidase (MMP)-9 were detected as signature inflammatory markers in non-eosinophilic NP. Despite differences in inflammatory cytokine profile between eosinophilic and non-eosinophilic NP, the common upregulation of IL-5, CCL-11, IL-23, IL-2R alpha, VCAM-1, MMP-3 and MMP-9 were shown in NP compared to UP within the same subject. In the PCA, we observed that Th2 immune response was helpful in discriminating between nasal tissues in subtypes of CRS and that there was a partial overlap between non-eosinophilic NP and eosinophilic NP in terms of Th2 mediators. Conclusions: Commonly upregulated mediators in NP were Th2-associated, compared with UP regardless of CRS subtypes, whereas signature markers were distinct in each NP subtype. These findings imply that Th2 inflammatory responses may play a role in the development of NP regardless of CRSwNP subtypes.
引用
收藏
页码:201 / 211
页数:11
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