Adaptation to hydrogen peroxide enhances PC12 cell tolerance against oxidative damage

被引：37

作者：

Chen, ZH ^{[1
]}

Yoshida, Y ^{[1
]}

Saito, Y ^{[1
]}

Niki, E ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Human Stess Signal Res Ctr, Ikeda, Osaka 5638577, Japan

来源：

NEUROSCIENCE LETTERS | 2005年 / 383卷 / 03期

关键词：

adaptation; hydrogen peroxide; catalase; glutathione peroxidase;

D O I：

10.1016/j.neulet.2005.04.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The adaptive responses to H2O2 and the resulting protective effect against oxidative stress have been investigated using PC12 cells. Pretreatment of sublethal doses of H2O2 significantly protected PC12 cells against the cytotoxicity induced by lethal H2O2. The endogenous antioxidant defense systems, catalase and glutathione peroxidase, were enhanced quickly by the pretreatment of low doses of H2O2. This pretreatment also exerted protective effect against the oxidative insults induced by 6-hydroxydopamine and pairaquat, but not against alkyl peroxyl radicals. Our results, taken together, suggest that the stimulation by low dose of H2O2 enriches the cellular antioxidant defense systems, thereby enhancing cell tolerance against the forthcoming oxidative insults induced by H2O2 and related hydroxyl radicals. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：256 / 259

页数：4

共 22 条

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