Clonal and horizontal spread of the blaOXA-232 gene among Enterobacteriaceae in a Korean hospital

被引：36

作者：

Jeong, Seok Hoon ^{[1
,2
]}

Lee, Kyu Man ^{[3
]}

Lee, Jacob ^{[4
]}

Bae, Il Kwon ^{[5
]}

Kim, Jae-Seok ^{[3
]}

Kim, Han-Sung ^{[3
]}

Song, Wonkeun ^{[3
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Lab Med, Seoul 120749, South Korea

[2] Yonsei Univ, Coll Med, Res Inst Antimicrobial Resistance, Seoul 120749, South Korea

[3] Hallym Univ, Coll Med, Dept Lab Med, Chunchon, South Korea

[4] Hallym Univ, Coll Med, Dept Internal Med, Chunchon, South Korea

[5] Silla Univ, Dept Dent Hyg, Busan, South Korea

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2015年 / 82卷 / 01期

关键词：

OXA-48; OXA-232; Klebsiella pneumoniae ST14; ColE-type plasmid; D BETA-LACTAMASE; KLEBSIELLA-PNEUMONIAE; RESISTANCE; EMERGENCE; IMIPENEM;

D O I：

10.1016/j.diagmicrobio.2015.02.001

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

All 16 Klebsiella pneumoniae isolates and both Escherichia coli isolates harbored the bla(OXA-232) and bla(CTX-M-15) genes. Furthermore, all 16 Klebsiella pneumoniae isolates belonged to a unique pulsed-field gel electrophoresis clone and were assigned to an identical sequence type (ST14). The 2 Escherichia coli isolates were identified as ST131 and ST457. The bla(OXA-232) gene underwent horizontal transfer to Escherichia coli isolates via a conjugative ColE-type plasmid. The introduction of this Klebsiella pneumoniae ST14 strain to the Korean hospital was attributed to an index patient who was likely colonized during a prior hospitalization in India. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：70 / 72

页数：3

共 12 条

[1] Early Dissemination of NDM-1-and OXA-181-Producing Enterobacteriaceae in Indian Hospitals: Report from the SENTRY Antimicrobial Surveillance Program, 2006-2007 [J].

Castanheira, Mariana ;

Deshpande, Lalitagauri M. ;

Mathai, Dilip ;

Bell, Jan M. ;

Jones, Ronald N. ;

Mendes, Rodrigo E. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (03) :1274-1278

[2]

Clinical and Laboratory Standards Institute (CLSI), 2012, PERFORMANCE STANDARD

[3] Detection of extended-spectrum beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli [J].

Jacoby, GA ;

Han, P .

JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (04) :908-911

[4] Prevalence of Plasmid-mediated Quinolone Resistance and Its Association with Extended-spectrum Beta-lactamase and AmpC Beta-lactamase in Enterobacteriaceae [J].

Jeong, Haeng Soon ;

Bae, Il Kwon ;

Shin, Jeong Hwan ;

Jung, Hee Jung ;

Kim, Si Hyun ;

Lee, Ja Young ;

Oh, Seung Hwan ;

Kim, Hye Ran ;

Chang, Chulhun Ludgerus ;

Kho, Weon-Gyu ;

Lee, Jeong Nyeo .

KOREAN JOURNAL OF LABORATORY MEDICINE, 2011, 31 (04) :257-264

[5] High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of blaACT-1 β-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin PhoE [J].

Kaczmarek, Frank M. ;

Dib-Hajj, Fadia ;

Shang, Wenchi ;

Gootz, Thomas D. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (10) :3396-3406

[6] Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-β-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp. [J].

Lee, K ;

Lim, YS ;

Yong, D ;

Yum, JH ;

Chong, Y .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (10) :4623-4629

[7] Emergence of OXA-48-Type Carbapenemase-Producing Enterobacteriaceae in German Hospitals [J].

Pfeifer, Yvonne ;

Schlatterer, Kathrin ;

Engelmann, Elisabeth ;

Schiller, Reinhold A. ;

Frangenberg, Hans Reiner ;

Stiewe, Doris ;

Holfelder, Martin ;

Witte, Wolfgang ;

Nordmann, Patrice ;

Poirel, Laurent .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (04) :2125-2128

[8] Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae [J].

Poirel, L ;

Héritier, C ;

Tolün, V ;

Nordmann, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (01) :15-22

[9] OXA-163, an OXA-48-Related Class D β-Lactamase with Extended Activity Toward Expanded-Spectrum Cephalosporins [J].

Poirel, Laurent ;

Castanheira, Mariana ;

Carrer, Amelie ;

Rodriguez, Carla Parada ;

Jones, Ronald N. ;

Smayevsky, Jorgelina ;

Nordmann, Patrice .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (06) :2546-2551

[10] Genetic and biochemical characterisation of OXA-232, a carbapenem-hydrolysing class D β-lactamase from Enterobacteriaceae [J].

Potron, Anais ;

Rondinaud, Emilie ;

Poirel, Laurent ;

Belmonte, Olivier ;

Boyer, Sophie ;

Camiade, Sabine ;

Nordmann, Patrice .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2013, 41 (04) :325-329

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