New anthracycline disaccharides. Synthesis of L-daunosaminyl-alpha(1->4)-2-deoxy-L-rhamnosyl and of L-daunosaminyl-alpha(1->4)-2-deoxy-L-fucosyl daunorubicin analogues

被引：31

作者：

Animati, F ^{[1
]}

Arcamone, F ^{[1
]}

Berettoni, M ^{[1
]}

Cipollone, A ^{[1
]}

Franciotti, M ^{[1
]}

Lombardi, P ^{[1
]}

机构：

[1] MENARINI RIC SPA,I-00040 POMEZIA,ROME,ITALY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1996年 / 12期

关键词：

D O I：

10.1039/p19960001327

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the new disaccharide anthracyclines 20, 21, 24 and 25, where the daunosamine moiety is separated from the aglycone by either a rhamnose or a fucose residue, performed following a convergent procedure, gives insight into the configurational requirement of the first sugar residue and opens the way to a new class of antitumour anthracyclines.

引用

页码：1327 / 1329

页数：3

共 23 条

[1]

ANIMATI F, 1996, 9 NCI EORTC S NEW DR

[2]

Arcamone F., 1981, MED CHEM SERIES, V17

[3]

Arcamone F, 1970, GAZZ CHIM ITAL, V100, P949

[4] APPROACH TO THE SYNTHESIS OF OLIGOSACCHARIDIC ANTHRACYCLINES - HEMISYNTHESIS OF 4'-O-(2-DEOXY-L-FUCOSYL)DAUNORUBICINE [J].