Solvent and ligand effects on selective mono- and dilithiation of 1-(chlorophenyl)pyrroles and 1-(methoxyphenyl)pyrroles

被引：25
作者：
Fogassy, K
Kovács, K
Keseru, GM
Toke, L
Faigl, F [1 ]
机构：
[1] Budapest Univ Technol & Econ, Dept Organ Chem Technol, H-1521 Budapest, Hungary
[2] Budapest Univ Technol & Econ, Dept Chem Informat Technol, H-1521 Budapest, Hungary
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 09期
关键词：
D O I：
10.1039/b100008j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel methods for site-selective lithiation of 1-(chlorophenyl)pyrroles and 1-(methoxyphenyl)pyrroles are described. Mono- or dilithiations are governed by change of both the temperature and the solvent from tetrahydrofuran to diethyl ether. Regioselectivities could be influenced by the quality of the metallating agent. Thus, 1-(4-chlorophenyl)pyrrole was dilithiated with activated butyllithium at 0 degreesC to afford a valuable intermediate in a pyrrolobenzoxazepine synthesis.
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页码：1039 / 1043
页数：5
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