Changes in brain activity related to episodic memory retrieval in adults with single domain amnestic mild cognitive impairment

被引：3

作者：

Angel Rivas-Fernandez, Miguel ^{[1
]}

Lindin, Monica ^{[1
]}

Diaz, Fernando ^{[1
]}

Zurron, Montserrat ^{[1
]}

Galdo-Alvarez, Santiago ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Psicoloxia, Dept Psicoloxia Clin & Psicobiol, Lab Neurociencia Cognit, Galicia, Spain

来源：

BIOLOGICAL PSYCHOLOGY | 2021年 / 166卷

关键词：

Alzheimer's disease; Brain activity changes; Episodic memory; Functional magnetic resonance imaging (fMRI); Single domain amnestic mild cognitive impairment (sdaMCI); FRONTOPARIETAL NETWORK; ALZHEIMERS-DISEASE; FMRI; SUBTYPES; ACTIVATION; STATE; RECOLLECTION; RECOGNITION; DIAGNOSIS; PATTERNS;

D O I：

10.1016/j.biopsycho.2021.108208

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The present fMRI study aimed to characterize the performance and the brain activity changes related to episodic memory retrieval in adults with single domain aMCI (sdaMCI), relative to cognitively unimpaired adults. Participants performed an old/new recognition memory task with words while BOLD signal was acquired. The sdaMCI group showed lower hits (correct recognition of old words), lower ability to discriminate old and new words, higher errors and longer reaction times for hits. This group also displayed brain hypoactivation in left precuneus and the left midcingulate cortex during the successful recognition of old words. These changes in brain activity suggest the presence of neural dysregulations in brain regions involved during successful episodic memory retrieval. Moreover, hypoactivation in these brain areas discriminated both groups with moderate sensitivity and specificity values, suggesting that it might constitute a potential neurocognitive biomarker of sdaMCI.

引用

页数：12

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