Prognostic significance of early molecular response in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

被引：3

作者：

Yeung, David T. ^{[1
,2
]}

Mauro, Michael J. ^{[3
]}

机构：

[1] SA Pathol, Dept Haematol & Mol Pathol, Adelaide, SA, Australia

[2] Univ Adelaide, Sch Med, Discipline Med, Adelaide, SA, Australia

[3] Mem Sloan Kettering Canc Ctr, Myeloproliferat Neoplasms Program, New York, NY 10065 USA

来源：

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM | 2014年

基金：

英国医学研究理事会;

关键词：

BCR-ABL1 TRANSCRIPT LEVELS; FOLLOW-UP; IMATINIB; CML; PREDICT; DISCONTINUATION; RECOMMENDATIONS; DASATINIB; NILOTINIB; SURVIVAL;

D O I：

10.1182/asheducation-2014.1.240

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

A 55-year-old man presented with splenomegaly (10 cm below left costal margin) and leucocytosis (145 x 10(9)/L). Differential showed neutrophilia with increased basophils (2%), eosinophils (1.5%), and left shift including myeloblasts (3%). A diagnosis of chronic myeloid leukemia in chronic phase was established after marrow cytogenetics demonstrated the Philadelphia chromosome. Molecular studies showed a BCR-ABL1 qPCR result of 65% on the International Scale. Imatinib therapy at 400 mg daily was initiated due to patient preference, with achievement of complete hematological response after 4 weeks of therapy. BCR-ABL1 at 1 and 3 months after starting therapy was 37% and 13%, respectively (all reported on International Scale). Is this considered an adequate molecular response?

引用

页码：240 / 243

页数：4

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