Dietary flaxseed supplementation improves endothelial function in the mesenteric arterial bed

被引：13

作者：

Daleprane, Julio Beltrame ^{[1
]}

Batista, Aline ^{[1
]}

Pacheco, Juliana Tomaz ^{[1
]}

da Silva, Andrea F. E. ^{[2
]}

Costa, Cristiane A. ^{[2
]}

Resende, Angela de Castro ^{[2
]}

Boaventura, Gilson Teles ^{[1
]}

机构：

[1] Univ Fed Fluminense, Coll Nutr, Dept Nutr & Dietet, Expt Nutr Lab, BR-24020140 Rio De Janeiro, Brazil

[2] Univ Estado Rio De Janeiro, IBRAG, Dept Pharmacol & Psychobiol, BR-20551030 Rio De Janeiro, Brazil

来源：

FOOD RESEARCH INTERNATIONAL | 2010年 / 43卷 / 08期

关键词：

Flaxseed; Diet; Mesenteric arterial bed; Lipid profile; Endothelial function; POLYUNSATURATED FATTY-ACIDS; ALPHA-LINOLENIC ACID; HYPERCHOLESTEROLEMIC ATHEROSCLEROSIS; BLOOD-PRESSURE; OIL; PREVENTION; PROTEIN; OMEGA-3; SEED; RICH;

D O I：

10.1016/j.foodres.2010.06.004

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The aim of this study was to evaluate the influence of flaxseed diet supplementation on endothelial function in the mesentenc arterial bed of rats Twenty-four rats were divided into 3 groups Control Group (CG 10% protein 5% fiber 7% lipid) Flaxseed Group (FG supplemented with 25% flaxseed 10% protein 7% fiber 11% lipid) and Modified Control Group (MCG 10% protein 7% fiber 11% lipid) The blood was obtained by cardiac puncture (after 180 days) and the serum was separated for lipid profile analyses The vasodilator effect of acetylcholine (1100 pmol) was evaluated in the preconstricted isolated rat vascular bed FG showed a 47% increase in HDL C a 22% reduction in LDL-C a 23% reduction in triacylglycerols and an Increased (p<0 05) vasodilator response to acetylcholine in relation to the CG and CMG groups These results suggest that flaxseed has a cardioprotective effect by improving the blood lipid profile and endothelial function (C) 2010 Elsevier Ltd All rights reserved

引用

页码：2052 / 2056

页数：5

共 46 条

[11] Organic and Genetically Modified Soybean Diets: Consequences in Growth and in Hematological Indicators of Aged Rats [J].

Daleprane, Julio Beltrame ;

Feijo, Tatiana Silveira ;

Boaventura, Gilson Teles .

PLANT FOODS FOR HUMAN NUTRITION, 2009, 64 (01) :1-5

[12]

DUPASQUIER CM, 2009, BRIT J NUTR, V102, P361

[13] Flaxseed supplementation of rats during lactation changes the adiposity and glucose homeostasis of their offspring [J].

Figueiredo, Mariana Sarto ;

de Moura, Egberto Gaspar ;

Lisboa, Patricia Cristina ;

Troina, Aline Andrade ;

Trevenzoli, Isis Haras ;

Oliveira, Elaine ;

Boaventura, Gilson Teles ;

da Fonseca Passos, Magna Cottini .

LIFE SCIENCES, 2009, 85 (9-10) :365-371

[14] Prevention of hypertension and its complications: Theoretical basis and guidelines for treatment [J].

Flack, JM ;

Peters, R ;

Shafi, T ;

Alrefai, H ;

Nasser, SA ;

Crook, E .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (07) :S92-S98

[15] Dietary intervention strategies to modulate prostate cancer risk and prognosis [J].

Freedland, Stephen J. ;

Aronson, William J. .

CURRENT OPINION IN UROLOGY, 2009, 19 (03) :263-267

[16] PALMOLEIN AND GROUNDNUT OIL HAVE COMPARABLE EFFECTS ON BLOOD-LIPIDS AND PLATELET-AGGREGATION IN HEALTHY INDIAN SUBJECTS [J].

GHAFOORUNISSA ;

REDDY, V ;

SESIKARAN, B .

LIPIDS, 1995, 30 (12) :1163-1169

[17]

Hansen Christine, 2006, Adv Nurse Pract, V14, P51

[18] Long-chain conversion of [13C] linoleic acid and α-linolenic acid in response to marked changes in their dietary intake in men [J].

Hussein, N ;

Ah-Sing, E ;

Wilkinson, P ;

Leach, C ;

Griffin, BA ;

Millward, DJ .

JOURNAL OF LIPID RESEARCH, 2005, 46 (02) :269-280

[19]

ISIK AC, 2007, J PHARM PHARMACOL, V59, P1629

[20]

Jenkins DJA, 1999, AM J CLIN NUTR, V69, P395

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