ESCRTing proteins in the endocytic pathway

被引：246
作者：
Saksena, Surai [1 ]
Sun, Ji [2 ]
Chu, Tony [2 ]
Emr, Scott D. [1 ,2 ]
机构：
[1] Cornell Univ, Cornell Inst Cell & Mol Biol, Ithaca, NY 14853 USA
[2] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2007年 / 32卷 / 12期
关键词：
D O I：
10.1016/j.tibs.2007.09.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The endosomal sorting complex required for transport (ESCRT) machinery is highly conserved and its components have been found in all five major supergroups of eukaryotes. The three ESCRT complexes and associated proteins play critical roles in receptor down-regulation, retroviral budding, and other normal and pathological cellular processes. Besides monoubiquitin-dependent protein cargo recognition and sorting, the ESCRT machinery also appears to drive the formation of multivesicullar bodies (MVBs). Recent advances in the determination of the function and structure of the ESCRT complexes have improved our understanding of the molecular details underlying the assembly and regulation of the ESCRT machinery.
引用
收藏
页码：561 / 573
页数：13
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