1,3-Dipolar cycloadditions of MeOPEG-bounded azides

被引：27
|
作者：
Molteni, G [1 ]
Del Buttero, P [1 ]
机构：
[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
来源：
TETRAHEDRON | 2005年 / 61卷 / 21期
关键词：
azides; 1,3-dipolar cycloadditions; azoles; polymer-supported synthesis;
D O I：
10.1016/j.tet.2005.03.049
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,3-Dipolar cycloadditions of MeOPEG-supported azide 2 with a variety of dipolarophiles have been studied. 1-MeOPEG-supported 1,2,3-triazoles 4 and 5, 1,2,3,4-tetrazoles 12 and aziridine 14 were obtained in nearly quantitative yields. The removal of the MeOPEG moiety from the 1,2,3-triazole nucleus was achieved by acidic cleavage of the cycloadduct mixtures 4 and 5 giving 4- and 5-substituted-1,2,3-triazoles 6 and 7. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4983 / 4987
页数：5
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