Kinetic evidence for duplicity in ion transport

被引：20

作者：

Deng, G

Merritt, M

Yamashita, K

Janout, V

Sadownik, A

Regen, SL

机构：

[1] LEHIGH UNIV,DEPT CHEM,BETHLEHEM,PA 18015

[2] LEHIGH UNIV,ZETTLEMOYER CTR SURFACE STUDIES,BETHLEHEM,PA 18015

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1996年 / 118卷 / 13期

关键词：

D O I：

10.1021/ja9526877

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this paper, we report the results of a kinetic investigation of the ion transport properties of four sterol-oligo (ethylene glycol) conjugates that have been modeled after the heptaene macrolide antibiotic, Amphotericin B. Specifically, we report the activity of 1, 2, 3, and 4 in promoting the transport of Na+ across egg phosphatidylcholine bilayers as a function of their membrane concentration. Our kinetic results not only provide compelling evidence for the existence of two discrete forms of an active ionophore in each case but also serve as a cautionary note for interpreting ionophoric activity based on single-concentration experiments.

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收藏

页码：3307 / 3308

页数：2

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