Percutaneous penetration enhancers: An overview

被引：127

作者：

Thong, H.-Y. ^{[1
]}

Zhai, H. ^{[1
]}

Maibach, H. I. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Sch Med, Dept Dermatol, San Francisco, CA 94143 USA

来源：

SKIN PHARMACOLOGY AND PHYSIOLOGY | 2007年 / 20卷 / 06期

关键词：

transdermal drug delivery; chemical penetration enhancers; iontophoresis; sonophoration; electroporation; microneedles; liposomes; transferosomes; niosomes; ethosomes;

D O I：

10.1159/000107575

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Transdermal drug delivery is the controlled release of drugs through the skin to obtain therapeutic levels systematically. Several technological advances have been made in the recent decades to enhance percutaneous drug penetration. This overview focuses on the physical, biochemical, and chemical means of penetration enhancement, as well as the classification and mechanisms of chemical penetration enhancers, their application in transdermal drug delivery, and trends and development in penetration enhancement. Copyright (c) 2007 S. Karger AG, Basel.

引用

页码：272 / 282

页数：11

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