Two mixed valence diruthenium(ii,iii) isomeric complexes show different anticancer properties

被引：33
|
作者：
Barresi, Elisabetta [1 ]
Tolbatov, Iogann [2 ]
Marzo, Tiziano [1 ,3 ]
Zappelli, Elisa [1 ]
Marrone, Alessandro [4 ]
Re, Nazzareno [4 ]
Pratesi, Alessandro [5 ]
Martini, Claudia [1 ,3 ]
Taliani, Sabrina [1 ,3 ]
Da Settimo, Federico [1 ,3 ]
La Mendola, Diego [1 ]
机构：
[1] Univ Pisa, Dept Pharm, Via Bonanno Pisano 6, I-56126 Pisa, Italy
[2] Univ Bourgogne Franche Comte UBFC, Inst Chim Mol Univ Bourgogne ICMUB, Ave Alain Savary 9, Dijon, France
[3] Univ Pisa, CISUP Ctr Integraz Strumentaz Sci, Pisa, Italy
[4] Univ G dAnnunzio, Dipartimento Farm, Via Vestini, I-66100 Chieti, Italy
[5] Univ Pisa, Dept Chem & Ind Chem, Via G Moruzzi 13, I-56124 Pisa, Italy
来源：
DALTON TRANSACTIONS | 2021年 / 50卷 / 27期
关键词：
CANCER; IBUPROFEN; NAPROXEN; DRUGS; PROTEIN;
D O I：
10.1039/d1dt01492g
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this paper it is demonstrated that the nature of the ligands of two Ru-2(ii,iii) paddlewheel complexes dramatically affects the overall anticancer properties in cells. Herein, the complex [Ru-2(EB776)(4)Cl] was found to be more active against a glioblastoma model with respect to its isomer [Ru-2(EB106)(4)Cl]. These different effects depend on the steric hindrance, on the allowed conformations of the complexes and on the presence of hydrophilic regions in [Ru-2(EB776)(4)Cl], which overall lead to a lower "steric protection".
引用
收藏
页码：9643 / 9647
页数：5
相关论文
共 50 条
  • [41] Tuning the anticancer properties of Pt(II) complexes via structurally flexible N-(2-picolyl)salicylimine ligands
    Al-Rashdi, Kamelah S.
    Babgi, Bandar A.
    Ali, Ehab M. M.
    Davaasuren, Bambar
    Jedidi, Abdesslem
    Emwas, Abdul-Hamid M.
    Alrayyani, Maymounah A.
    Jaremko, Mariusz
    Humphrey, Mark G.
    Hussien, Mostafa A.
    RSC ADVANCES, 2022, 12 (42) : 27582 - 27595
  • [42] A study of the properties, reactivity and anticancer activity of novel N- methylated-3-thiazolyl or 3-thienyl carbazoles and their Pd(II) and Pt(II) complexes
    Reig, Marta
    Bosque, Ramon
    Font-Bardia, Merce
    Calvis, Carme
    Messeguer, Ramon
    Baldoma, Laura
    Badia, Josefa
    Velasco, Dolores
    Lopez, Concepcion
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2018, 184 : 134 - 145
  • [43] Unraveling the Anticancer Efficacy and Biomolecular Properties of Ru(II)-Arene Complexes of Pyrene-Based Thiosemicarbazone Ligands: A Comprehensive In Silico/In Vitro Exploration
    Palakkeezhillam, Vishnunarayanan Namboothiri Vadakkedathu
    Haribabu, Jebiti
    Kumar, Vaishnu Suresh
    Santibanez, Juan F.
    Manakkadan, Vipin
    Rasin, Puthiyavalappil
    Garg, Mohit
    Bhuvanesh, Nattamai
    Sreekanth, Anandaram
    ORGANOMETALLICS, 2024, 43 (03) : 242 - 260
  • [44] Synthesis, Characterization, DNA/HSA Interactions, and Anticancer Activity of Two Novel Copper(II) Complexes with 4-Chloro-3-Nitrobenzoic Acid Ligand
    Zeng, Zhen-Fang
    Huang, Qiu-Ping
    Cai, Jie-Hui
    Zheng, Guang-Jin
    Huang, Qiu-Chan
    Liu, Zi-Lu
    Chen, Zi-Lu
    Wei, You-Huan
    MOLECULES, 2021, 26 (13):
  • [45] Half-Sandwich Iridium(III), Rhodium(III), and Ruthenium(II) Complexes Chelating Hybrid sp2-N/sp3-N Donor Ligands to Achieve Improved Anticancer Selectivity
    Guo, Lihua
    Li, Pengwei
    Li, Jiaxing
    Gong, Yuwen
    Li, Xiaoyuan
    Liu, Yiming
    Yu, Kaijian
    Liu, Zhe
    INORGANIC CHEMISTRY, 2023, 62 (37) : 15118 - 15137
  • [46] Potent Half-Sandwich 16-/18-Electron Iridium(III) and Ruthenium(II) Anticancer Complexes with Readily Available Amine-Imine Ligands
    Guo, Lihua
    Li, Pengwei
    Li, Jiaxing
    Gong, Yuwen
    Li, Xiaoyuan
    Wen, Tingjun
    Wu, Xinxin
    Yang, Xinyi
    Liu, Zhe
    INORGANIC CHEMISTRY, 2023, 62 (51) : 21379 - 21395
  • [47] Synthesis, X-ray structure, physicochemical properties and anticancer activity of mer and fac Ru(iii) triphenylphosphine complexes with a benzothiazole derivative as a co-ligand
    Richert, Monika
    Walczyk, Mariusz
    Cieslak, Marcin Janusz
    Kazmierczak-Baranska, Julia
    Krolewska-Golinska, Karolina
    Wrzeszcz, Grzegorz
    Muziol, Tadeusz
    Biniak, Stanistaw
    DALTON TRANSACTIONS, 2019, 48 (28) : 10689 - 10702
  • [48] Highly water-soluble platinum(II) complexes as GLUT substrates for targeted therapy: improved anticancer efficacy and transporter-mediated cytotoxic properties
    Liu, Pengxing
    Lu, Yanhui
    Gao, Xiangqian
    Liu, Ran
    Zhang-Negrerie, Daisy
    Shi, Ying
    Wang, Yiqiang
    Wang, Songqing
    Gao, Qingzhi
    CHEMICAL COMMUNICATIONS, 2013, 49 (24) : 2421 - 2423
  • [49] Hybrid organoruthenium(II) complexes with thiophene-β-diketo-benzazole ligands: Synthesis, optical properties, CT-DNA interactions and anticancer activity
    Ismail, Lamia A.
    Alfaifi, Mohammad Y.
    Elbehairi, Serag Eldin, I
    Elshaarawy, Reda F. M.
    Gad, Emad M.
    El-Sayed, W. N.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2021, 949
  • [50] Synthesis, crystal structures, anticancer activities and molecular docking studies of novel thiazolidinone Cu(ii) and Fe(iii) complexes targeting lysosomes: special emphasis on their binding to DNA/BSA
    Shao, Jia
    Zhang, Qiang
    Wei, Jing
    Yuchi, Zhiguang
    Cao, Peng
    Li, Shao-Qing
    Wang, Shan
    Xu, Jing-Yuan
    Yang, Shuang
    Zhang, Yi
    Wei, Jin-Xia
    Tian, Jin-Lei
    DALTON TRANSACTIONS, 2021, 50 (38) : 13387 - 13398
12345