Two mixed valence diruthenium(ii,iii) isomeric complexes show different anticancer properties

被引：33
|
作者：
Barresi, Elisabetta [1 ]
Tolbatov, Iogann [2 ]
Marzo, Tiziano [1 ,3 ]
Zappelli, Elisa [1 ]
Marrone, Alessandro [4 ]
Re, Nazzareno [4 ]
Pratesi, Alessandro [5 ]
Martini, Claudia [1 ,3 ]
Taliani, Sabrina [1 ,3 ]
Da Settimo, Federico [1 ,3 ]
La Mendola, Diego [1 ]
机构：
[1] Univ Pisa, Dept Pharm, Via Bonanno Pisano 6, I-56126 Pisa, Italy
[2] Univ Bourgogne Franche Comte UBFC, Inst Chim Mol Univ Bourgogne ICMUB, Ave Alain Savary 9, Dijon, France
[3] Univ Pisa, CISUP Ctr Integraz Strumentaz Sci, Pisa, Italy
[4] Univ G dAnnunzio, Dipartimento Farm, Via Vestini, I-66100 Chieti, Italy
[5] Univ Pisa, Dept Chem & Ind Chem, Via G Moruzzi 13, I-56124 Pisa, Italy
来源：
DALTON TRANSACTIONS | 2021年 / 50卷 / 27期
关键词：
CANCER; IBUPROFEN; NAPROXEN; DRUGS; PROTEIN;
D O I：
10.1039/d1dt01492g
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this paper it is demonstrated that the nature of the ligands of two Ru-2(ii,iii) paddlewheel complexes dramatically affects the overall anticancer properties in cells. Herein, the complex [Ru-2(EB776)(4)Cl] was found to be more active against a glioblastoma model with respect to its isomer [Ru-2(EB106)(4)Cl]. These different effects depend on the steric hindrance, on the allowed conformations of the complexes and on the presence of hydrophilic regions in [Ru-2(EB776)(4)Cl], which overall lead to a lower "steric protection".
引用
收藏
页码：9643 / 9647
页数：5
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