Hypoglycemic and Hypolipidemic Activity of Pongamia pinnata (Linn.) Pierre in Streptozotocin-induced Diabetic Rats

被引：0
作者：
Kumar, P. [1 ]
Semalty, A. [1 ]
Mir, S. R. [2 ]
Ali, M. [2 ]
Amin, S. [2 ]
机构：
[1] HNB Garhwal Univ, Dept Pharmaceut Sci, Srinagar 246174, Garhwal, India
[2] Jamia Hamdard, Fac Pharm, New Delhi, India
来源：
INTERNATIONAL JOURNAL OF PHARMACOLOGY | 2010年 / 6卷 / 05期
关键词：
Pongamia pinnata; Karanja; hypolipidemic; antidiabetic activity; streptozotocin; PROJECTIONS; PREVALENCE; EXTRACTS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The plant Pongamia pinnata (Linn.) Pierre of family Leguminosae sub-family Papilioanaceae was evaluated for its hypoglycemic and hypolipidemic activity in streptozotocin induced diabetic rats. A new difuranoflavonone Compound PP (named Pongamiaflavonol), isolated from methanlolic extract of P. pinnata pods by column chromatography, was also studied for the activity. It was observed that after 14 days of treatment blood glucose level was reduced by 66.34, 54.82, 63.62 and 67.48 % with Std. Glibenclamiade 3 mg kg(-1)), P. pinnata pods (300 mg kg(-1)), P. pinnata flowers (300 mg kg(-1)) and PP (100 mg kg(-1)), respectively. The lipid profile was also studied and was found to be normalized significantly by both the flowers and pods extracts of P. pinnata and compound PP.
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页码：738 / 743
页数：6
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