Study of the thermal decomposition on Pt(II) complexes with cycloalkanespiro-5'-hydantoins

被引:6
作者
Bakalova, A. [1 ]
Ivanov, D. [1 ]
机构
[1] Med Univ, Fac Pharm, Dept Chem, BU-1000 Sofia, Bulgaria
关键词
Pt(II) complexes; spirohydantoins; thermal analysis;
D O I
10.1007/s10973-005-7474-1
中图分类号
O414.1 [热力学];
学科分类号
摘要
The thermal decomposition of the Pt(II) complexes with cyclobutane-and cycloheptanespiro-5'-hydantoins were studied by TG and DTA techniques. The Pt(II) complex with cyclobutanespiro-5'hydantoin (PtCBH) was stable up to 115 degrees C (388 K) and Pt(II) complex with cycloheptanespiro-5'-hydantoin (PtCHTH) was stable up to 150 degrees C (423 K). After the thermal decomposition of PtCBH the solid residue was platinum, while the decomposition of PtCHTH gave a mixture of platinum carbides (PtC2, Pt2C3).
引用
收藏
页码:257 / 260
页数:4
相关论文
共 13 条
  • [1] Synthesis, physicochemical and in vitro pharmacological investigation of new platinum (II) complexes with some cycloalkanespiro-5′-hydantoins
    Bakalova, A
    Buyukliev, R
    Momekov, G
    Ivanov, D
    Todorov, D
    Konstantinov, S
    Karaivanova, M
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (06) : 590 - 596
  • [2] Boulikas T, 2003, ONCOL REP, V10, P1663
  • [3] BRAUER G, 1980, HDB ANORGANISCHE SYN, P1818
  • [4] Canal P, 1998, CLINICIAN'S GUIDE TO CHEMOTHERAPY PHARMACOKINETICS AND PHARMACODYNAMICS, P345
  • [5] COLVIN D, 1998, CANC MED, P648
  • [6] Particular aspects of platinum compounds used at present in cancer treatment
    Desoize, B
    Madoulet, C
    [J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2002, 42 (03) : 317 - 325
  • [7] Hanigan Marie H, 2003, Cancer Ther, V1, P47
  • [8] Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate
    Howell, B. A.
    Fan, D.
    Rakesh, Leela
    [J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2006, 85 (01) : 17 - 20
  • [9] SAHU BR, 2005, PHYS REV B, V15, P71
  • [10] TOLSTYKH, 1995, EXCERPTS NOTES B