Topiramate in benzodiazepine withdrawal

被引：15

作者：

Cheseaux, M

Monnat, M

Zullino, DF ^{[1
]}

机构：

[1] Dept Univ Psychiat Adulte, Div Abus Subst, Clin Cery, CH-1008 Prilly, Switzerland

[2] Policlin Med Univ, Lausanne, Switzerland

来源：

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | 2003年 / 18卷 / 05期

关键词：

anticonvulsant; substance abuse; AMPA receptor; benzodiazepine withdrawal; detoxitication;

D O I：

10.1002/hup.497

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is an increasing interest in anticonvulsants for the treatment of benzodiazepine withdrawal symptoms. The new anticonvulsant compound topiramate seems to be an especially promising drug for this indication. It acts, among others, as an AMPA antagonist, which may be responsible in part for its anticonvulsant efficacy, but may also modulate the withdrawal-induced activation of noradrenergic neurons in the locus coeruleus, which are related to some behavioural effects of benzodiazepine withdrawal. A case is presented of a rapid benzodiazepine-withdrawal treated successfully with topiramate. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：375 / 377

页数：3

共 15 条

[1]

KLEIN E, 1986, AM J PSYCHIAT, V143, P235

[2]

KRENZ SL, 2002, EUR PSYCHIAT, V17, P213

[3] Topiramate - A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of epilepsy [J].