AlphaFold heralds a data-driven revolution in biology and medicine

被引:113
作者
Thornton, Janet M. [1 ]
Laskowski, Roman A. [1 ]
Borkakoti, Neera [1 ]
机构
[1] European Bioinformat Inst, European Mol Biol Lab EMBL, South Bldg,Wellcome Genome Campus, Hinxton, England
关键词
D O I
10.1038/s41591-021-01533-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Protein structures predicted using artificial intelligence will aid medical research, but the greatest benefit will come if clinical data can be similarly used to better understand human disease.
引用
收藏
页码:1666 / 1669
页数:4
相关论文
共 20 条
[1]   Machine learning in protein structure prediction [J].
AlQuraishi, Mohammed .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2021, 65 :1-8
[2]  
[Anonymous], COVID 19 PROTEIN STR
[3]  
[Anonymous], DARWIN TREE LIFE
[4]  
[Anonymous], CASP14 14 COMMUNITY
[5]   Accurate prediction of protein structures and interactions using a three-track neural network [J].
Baek, Minkyung ;
DiMaio, Frank ;
Anishchenko, Ivan ;
Dauparas, Justas ;
Ovchinnikov, Sergey ;
Lee, Gyu Rie ;
Wang, Jue ;
Cong, Qian ;
Kinch, Lisa N. ;
Schaeffer, R. Dustin ;
Millan, Claudia ;
Park, Hahnbeom ;
Adams, Carson ;
Glassman, Caleb R. ;
DeGiovanni, Andy ;
Pereira, Jose H. ;
Rodrigues, Andria V. ;
van Dijk, Alberdina A. ;
Ebrecht, Ana C. ;
Opperman, Diederik J. ;
Sagmeister, Theo ;
Buhlheller, Christoph ;
Pavkov-Keller, Tea ;
Rathinaswamy, Manoj K. ;
Dalwadi, Udit ;
Yip, Calvin K. ;
Burke, John E. ;
Garcia, K. Christopher ;
Grishin, Nick V. ;
Adams, Paul D. ;
Read, Randy J. ;
Baker, David .
SCIENCE, 2021, 373 (6557) :871-+
[6]   UniProt: the universal protein knowledgebase in 2021 [J].
Bateman, Alex ;
Martin, Maria-Jesus ;
Orchard, Sandra ;
Magrane, Michele ;
Agivetova, Rahat ;
Ahmad, Shadab ;
Alpi, Emanuele ;
Bowler-Barnett, Emily H. ;
Britto, Ramona ;
Bursteinas, Borisas ;
Bye-A-Jee, Hema ;
Coetzee, Ray ;
Cukura, Austra ;
Da Silva, Alan ;
Denny, Paul ;
Dogan, Tunca ;
Ebenezer, ThankGod ;
Fan, Jun ;
Castro, Leyla Garcia ;
Garmiri, Penelope ;
Georghiou, George ;
Gonzales, Leonardo ;
Hatton-Ellis, Emma ;
Hussein, Abdulrahman ;
Ignatchenko, Alexandr ;
Insana, Giuseppe ;
Ishtiaq, Rizwan ;
Jokinen, Petteri ;
Joshi, Vishal ;
Jyothi, Dushyanth ;
Lock, Antonia ;
Lopez, Rodrigo ;
Luciani, Aurelien ;
Luo, Jie ;
Lussi, Yvonne ;
Mac-Dougall, Alistair ;
Madeira, Fabio ;
Mahmoudy, Mahdi ;
Menchi, Manuela ;
Mishra, Alok ;
Moulang, Katie ;
Nightingale, Andrew ;
Oliveira, Carla Susana ;
Pundir, Sangya ;
Qi, Guoying ;
Raj, Shriya ;
Rice, Daniel ;
Lopez, Milagros Rodriguez ;
Saidi, Rabie ;
Sampson, Joseph .
NUCLEIC ACIDS RESEARCH, 2021, 49 (D1) :D480-D489
[7]   A Structure-Based Drug Discovery Paradigm [J].
Batool, Maria ;
Ahmad, Bilal ;
Choi, Sangdun .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (11)
[8]   Protein Data Bank: the single global archive for 3D macromolecular structure data [J].
Burley, Stephen K. ;
Berman, Helen M. ;
Bhikadiya, Charmi ;
Bi, Chunxiao ;
Chen, Li ;
Di Costanzo, Luigi ;
Christie, Cole ;
Duarte, Jose M. ;
Dutta, Shuchismita ;
Feng, Zukang ;
Ghosh, Sutapa ;
Goodsell, David S. ;
Green, Rachel Kramer ;
Guranovic, Vladimir ;
Guzenko, Dmytro ;
Hudson, Brian P. ;
Liang, Yuhe ;
Lowe, Robert ;
Peisach, Ezra ;
Periskova, Irina ;
Randle, Chris ;
Rose, Alexander ;
Sekharan, Monica ;
Shao, Chenghua ;
Tao, Yi-Ping ;
Valasatava, Yana ;
Voigt, Maria ;
Westbrook, John ;
Young, Jasmine ;
Zardecki, Christine ;
Zhuravleva, Marina ;
Kurisu, Genji ;
Nakamura, Haruki ;
Kengaku, Yumiko ;
Cho, Hasumi ;
Sato, Junko ;
Kim, Ju Yaen ;
Ikegawa, Yasuyo ;
Nakagawa, Atsushi ;
Yamashita, Reiko ;
Kudou, Takahiro ;
Bekker, Gert-Jan ;
Suzuki, Hirofumi ;
Iwata, Takeshi ;
Yokochi, Masashi ;
Kobayashi, Naohiro ;
Fujiwara, Toshimichi ;
Velankar, Sameer ;
Kleywegt, Gerard J. ;
Anyango, Stephen .
NUCLEIC ACIDS RESEARCH, 2019, 47 (D1) :D520-D528
[9]  
Diwan G. D., 2021, J MOL BIOL
[10]   The druggable genome [J].
Hopkins, AL ;
Groom, CR .
NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (09) :727-730