Sphingolipid metabolism, transport, and functions in Recent and future

被引：51

作者：

Liu, Ning-Jing ^{[1
]}

Hou, Li-Pan ^{[1
,2
]}

Bao, Jing-Jing ^{[1
,2
]}

Wang, Ling-Jian ^{[1
]}

Chen, Xiao-Ya ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Plant Physiol & Ecol, CAS Ctr Excellence Mol Plant Sci, State Key Lab Plant Mol Genet, Fenglin Rd 300, Shanghai 200032, Peoples R China

[2] Univ Chinese Acad Sci, Shanghai 200032, Peoples R China

来源：

PLANT COMMUNICATIONS | 2021年 / 2卷 / 05期

基金：

中国国家自然科学基金;

关键词：

sphingolipid metabolism; membrane lateral heterogeneity; vesicular and non-vesicular trafficking; PROGRAMMED CELL-DEATH; MEMBRANE-LIPID COMPOSITION; CHAIN BASE KINASE; PLASMA-MEMBRANE; SERINE PALMITOYLTRANSFERASE; PLANT SPHINGOLIPIDS; GLUCOSYLCERAMIDE BIOSYNTHESIS; ARABIDOPSIS-THALIANA; GUARD-CELLS; PROTEIN;

D O I：

10.1016/j.xplc.2021.100214

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingolipids, which comprise membrane systems together with other lipids, are ubiquitous in cellular organisms. They show a high degree of diversity across plant species and vary in their structures, properties, and functions. Benefiting from the development of lipidomic techniques, over 300 plant sphingolipids have been identified. Generally divided into free long-chain bases (LCBs), ceramides, glycosylceramides (GlcCers) and glycosyl inositol phosphoceramides (GIPCs), plant sphingolipids exhibit organized aggregation within lipid membranes to form raft domains with sterols. Accumulating evidence has revealed that sphingolipids obey certain trafficking and distribution rules and confer unique properties to membranes. Functional studies using sphingolipid biosynthetic mutants demonstrate that sphingolipids participate in plant developmental regulation, stimulus sensing, and stress responses. Here, we present an updated metabolism/degradation map and summarize the structures of plant sphingolipids, review recent progress in understanding the functions of sphingolipids in plant development and stress responses, and review sphingolipid distribution and trafficking in plant cells. We also highlight some important challenges and issues that we may face during the process of studying sphingolipids.

引用

页数：17