Selective Inhibitors of Nuclear Export in the Treatment of Hematologic Malignancies

被引:13
作者
Allegra, Alessandro [1 ]
Innao, Vanessa [1 ]
Allegra, Andrea Gaetano [1 ]
Leanza, Rossana [1 ]
Musolino, Caterina [1 ]
机构
[1] Univ Messina, Dept Human Pathol Adulthood & Childhood Gaetano B, Div Hematol, Messina, Italy
关键词
Exportin; 1; Karyopherins; Leukemia; Multiple myeloma; Selinexor; ACUTE MYELOID-LEUKEMIA; TOPOISOMERASE-II-ALPHA; B-CELL LYMPHOMA; WILD-TYPE P53; BCR-ABL; CYTOPLASMIC LOCALIZATION; SUBCELLULAR-LOCALIZATION; RECURRENT MUTATIONS; XPO1; INHIBITION; CRM1; INHIBITOR;
D O I
10.1016/j.clml.2019.08.011
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The correct localization of molecules between nucleus and cytoplasm is fundamental for cellular homeostasis and is controlled by a bidirectional transport system. Exportin 1 (XPO1) regulates the passage of numerous cancer-related proteins. In this review, we summarize the development of a novel class of antitumor agents, known as selective inhibitors of nuclear export (SINEs). We report results of preclinical studies and clinical trials, and discuss the mechanism of action of SINEs and their effects in multiple myeloma, non-Hodgkin lymphomas, lymphoblastic leukemia, and acute and chronic myeloid leukemia. In the future, the numerous experimental studies currently underway will allow us to define the role of SINEs and will possibly permit these substances to be introduced into daily clinical practice.
引用
收藏
页码:E689 / E698
页数:10
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