The correct localization of molecules between nucleus and cytoplasm is fundamental for cellular homeostasis and is controlled by a bidirectional transport system. Exportin 1 (XPO1) regulates the passage of numerous cancer-related proteins. In this review, we summarize the development of a novel class of antitumor agents, known as selective inhibitors of nuclear export (SINEs). We report results of preclinical studies and clinical trials, and discuss the mechanism of action of SINEs and their effects in multiple myeloma, non-Hodgkin lymphomas, lymphoblastic leukemia, and acute and chronic myeloid leukemia. In the future, the numerous experimental studies currently underway will allow us to define the role of SINEs and will possibly permit these substances to be introduced into daily clinical practice.
机构:
St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Alexander, Thomas B.
Lacayo, Norman J.
论文数: 0引用数: 0
h-index: 0
机构:
Lucile Packard Childrens Hosp Stanford, Stanford, CA USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Lacayo, Norman J.
Choi, John K.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Choi, John K.
Ribeiro, Raul C.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Univ Tennessee, Coll Med, Memphis, TN USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Ribeiro, Raul C.
Pui, Ching-Hon
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Univ Tennessee, Coll Med, Memphis, TN USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Pui, Ching-Hon
Rubnitz, Jeffrey E.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Univ Tennessee, Coll Med, Memphis, TN USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
机构:
Univ Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, ItalyUniv Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, Italy
Gerace, Demetrio
Vaddinelli, Doriana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, ItalyUniv Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, Italy
Vaddinelli, Doriana
Musolino, Caterina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, ItalyUniv Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, Italy
机构:
St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Alexander, Thomas B.
Lacayo, Norman J.
论文数: 0引用数: 0
h-index: 0
机构:
Lucile Packard Childrens Hosp Stanford, Stanford, CA USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Lacayo, Norman J.
Choi, John K.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Choi, John K.
Ribeiro, Raul C.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Univ Tennessee, Coll Med, Memphis, TN USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Ribeiro, Raul C.
Pui, Ching-Hon
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Univ Tennessee, Coll Med, Memphis, TN USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Pui, Ching-Hon
Rubnitz, Jeffrey E.
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Univ Tennessee, Coll Med, Memphis, TN USASt Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA
机构:
Univ Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, ItalyUniv Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, Italy
Gerace, Demetrio
Vaddinelli, Doriana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, ItalyUniv Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, Italy
Vaddinelli, Doriana
Musolino, Caterina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, ItalyUniv Messina, Div Hematol, Dipartimento Patol Umana Adulto & Eta Evolut, Messina, Italy