High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography

被引：31

作者：

Lawman, Samuel ^{[1
,2
]}

Dong, Yue ^{[1
]}

Williams, Bryan M. ^{[2
]}

Romano, Vito ^{[3
]}

Kaye, Stephen ^{[2
,3
]}

Harding, Simon P. ^{[2
,3
]}

Willoughby, Colin ^{[2
,3
]}

Shen, Yao-Chun ^{[1
]}

Zheng, Yalin ^{[2
,3
]}

机构：

[1] Univ Liverpool, Dept Elect Engn & Elect, Liverpool L69 3GJ, Merseyside, England

[2] Univ Liverpool, Dept Eye & Vis Sci, Liverpool L7 8TX, Merseyside, England

[3] Royal Liverpool Univ Hosp, St Pauls Eye Unit, Liverpool L7 8XP, Merseyside, England

来源：

OPTICS EXPRESS | 2016年 / 24卷 / 11期

基金：

英国工程与自然科学研究理事会; 美国国家卫生研究院;

关键词：

ENDOTHELIAL KERATOPLASTY; PHASE; TIME; SYSTEM; INTERFEROMETRY;

D O I：

10.1364/OE.24.012395

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 mu m in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts. (C)2016 Optical Society of America

引用

页码：2395 / 2405

页数：11

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