High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography

被引:31
作者
Lawman, Samuel [1 ,2 ]
Dong, Yue [1 ]
Williams, Bryan M. [2 ]
Romano, Vito [3 ]
Kaye, Stephen [2 ,3 ]
Harding, Simon P. [2 ,3 ]
Willoughby, Colin [2 ,3 ]
Shen, Yao-Chun [1 ]
Zheng, Yalin [2 ,3 ]
机构
[1] Univ Liverpool, Dept Elect Engn & Elect, Liverpool L69 3GJ, Merseyside, England
[2] Univ Liverpool, Dept Eye & Vis Sci, Liverpool L7 8TX, Merseyside, England
[3] Royal Liverpool Univ Hosp, St Pauls Eye Unit, Liverpool L7 8XP, Merseyside, England
来源
OPTICS EXPRESS | 2016年 / 24卷 / 11期
基金
英国工程与自然科学研究理事会; 美国国家卫生研究院;
关键词
ENDOTHELIAL KERATOPLASTY; PHASE; TIME; SYSTEM; INTERFEROMETRY;
D O I
10.1364/OE.24.012395
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 mu m in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human cornea sample ex-vivo. The single pulse setup is applied to imaging of a coated pharmaceutical tablet. The fixed pattern noise due to spectral noise is removed by subtracting the median magnitude A-Scan. We also demonstrate that the Fourier phase can be used to remove aberration caused artefacts. (C)2016 Optical Society of America
引用
收藏
页码:2395 / 2405
页数:11
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