Prevalence of Metabolic Syndrome and Its Association with Physical Capacity, Disability, and Self-Rated Health in Lifestyle Interventions and Independence for Elders Study Participants

被引：28

作者：

Botoseneanu, Anda ^{[1
,2
,3
]}

Ambrosius, Walter T. ^{[4
]}

Beavers, Daniel P. ^{[4
]}

de Rekeneire, Nathalie ^{[3
]}

Anton, Stephen ^{[5
]}

Church, Timothy ^{[6
]}

Folta, Sara C. ^{[7
]}

Goodpaster, Bret H. ^{[8
]}

King, Abby C. ^{[9
,10
]}

Nicklas, Barbara J. ^{[11
]}

Spring, Bonnie ^{[12
]}

Wang, Xuewen ^{[13
]}

Gill, Thomas M. ^{[3
]}

机构：

[1] Univ Michigan, Dept Hlth Policy Studies, Dearborn, MI 48128 USA

[2] Univ Michigan, Inst Gerontol, Dearborn, MI 48128 USA

[3] Yale Univ, Sch Med, Dept Internal Med, Div Geriatr, New Haven, CT 06510 USA

[4] Wake Forest Univ, Dept Biostat Sci, Winston Salem, NC 27109 USA

[5] Univ Florida, Inst Aging, Dept Aging & Geriatr Res, Gainesville, FL USA

[6] Louisiana State Univ, Baton Rouge, LA 70803 USA

[7] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA

[8] Sanford I Burnham Med Res Inst, Metab Dis Program, Orlando, FL USA

[9] Stanford Univ, Sch Med, Stanford Prevent Res Ctr, Dept Hlth Res & Policy, Stanford, CA 94305 USA

[10] Stanford Univ, Dept Med, Stanford Prevent Res Ctr, Sch Med, Stanford, CA 94305 USA

[11] Wake Forest Univ, Bowman Gray Sch Med, J Paul Sticht Ctr Aging, Winston Salem, NC USA

[12] Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA

[13] Univ S Carolina, Dept Exercise Sci, Columbia, SC 29208 USA

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2015年 / 63卷 / 02期

基金：

美国国家卫生研究院;

关键词：

metabolic syndrome; mobility disability; grip strength; Short Physical Performance Battery; self-rated health; LOWER-EXTREMITY FUNCTION; MIDDLE-AGED MEN; OLDER-ADULTS; GAIT SPEED; PERFORMANCE BATTERY; FUNCTIONAL ABILITY; SYNDROME DIFFER; WOMENS HEALTH; GRIP STRENGTH; NHANES-III;

D O I：

10.1111/jgs.13205

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

ObjectivesTo evaluate the prevalence of metabolic syndrome (MetS) and its association with physical capacity, disability, and self-rated health in older adults at high risk of mobility disability, including those with and without diabetes mellitus. DesignCross-sectional analysis. SettingLifestyle Interventions and Independence for Elders (LIFE) Study. ParticipantsCommunity-dwelling sedentary adults aged 70 to 89 at high risk of mobility disability (Short Physical Performance Battery (SPPB) score 9; mean 7.41.6) (N=1,535). MeasurementsMetabolic syndrome was defined according to the 2009 multiagency harmonized criteria; outcomes were physical capacity (400-m walk time, grip strength, SPPB score), disability (composite 19-item score), and self-rated health (5-point scale ranging from excellent to poor). ResultsThe prevalence of MetS was 49.8% in the overall sample (83.2% of those with diabetes mellitus, 38.1% of those without). MetS was associated with stronger grip strength (mean difference ()=1.2kg, P=.01) in the overall sample and in participants without diabetes mellitus and with poorer self-rated health (=0.1kg, P<.001) in the overall sample only. No significant differences were found in 400-m walk time, SPPB score, or disability score between participants with and without MetS, in the overall sample or diabetes mellitus subgroups. ConclusionMetabolic dysfunction is highly prevalent in older adults at risk of mobility disability, yet consistent associations were not observed between MetS and walking speed, lower extremity function, or self-reported disability after adjusting for known and potential confounders. Longitudinal studies are needed to investigate whether MetS accelerates declines in functional status in high-risk older adults and to inform clinical and public health interventions aimed at preventing or delaying disability in this group.

引用

页码：222 / 232

页数：11

共 47 条

[1] Measurement and Interpretation of the Ankle-Brachial Index A Scientific Statement From the American Heart Association [J].

Aboyans, Victor ;

Criqui, Michael H. ;

Abraham, Pierre ;

Allison, Matthew A. ;

Creager, Mark A. ;

Diehm, Curt ;

Fowkes, F. Gerry R. ;

Hiatt, William R. ;

Joensson, Bjoern ;

Lacroix, Philippe ;

Marin, Benoit ;

McDermott, Mary M. ;

Norgren, Lars ;

Pande, Reena L. ;

Preux, Pierre-Marie ;

Stoffers, H. E. ;

Treat-Jacobson, Diane .

CIRCULATION, 2012, 126 (24) :2890-+

[2] Overall Diet History and Reversibility of the Metabolic Syndrome Over 5 Years [J].

Akbaraly, Tasnime N. ;

Singh-Manoux, Archana ;

Tabak, Adam G. ;

Jokela, Markus ;

Virtanen, Marianna ;

Ferrie, Jane E. ;

Marmot, Michael G. ;

Shipley, Martin J. ;

Kivimaki, Mika .

DIABETES CARE, 2010, 33 (11) :2339-2341

[3] Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J].

Alberti, K. G. M. M. ;

Eckel, Robert H. ;

Grundy, Scott M. ;

Zimmet, Paul Z. ;

Cleeman, James I. ;

Donato, Karen A. ;

Fruchart, Jean-Charles ;

James, W. Philip T. ;

Loria, Catherine M. ;

Smith, Sidney C., Jr. .

CIRCULATION, 2009, 120 (16) :1640-1645

[4]

[Anonymous], 2009, National health statistics reports

[5] The Role of Metabolic Syndrome, Adiposity, and Inflammation in Physical Performance in the Health ABC Study [J].

Beavers, Kristen M. ;

Hsu, Fang-Chi ;

Houston, Denise K. ;

Beavers, Daniel P. ;

Harris, Tamara B. ;

Hue, Trisha F. ;

Kim, Lauren J. ;

Koster, Annemarie ;

Penninx, Brenda W. ;

Simonsick, Eleanor M. ;

Strotmeyer, Elsa S. ;

Kritchevsky, Stephen B. ;

Nicklas, Barbara J. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2013, 68 (05) :617-623

[6] Metabolic syndrome predicts mobility decline in a community-based sample of older adults [J].

Blazer, DG ;

Hybels, CF ;

Fillenbaum, GG .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2006, 54 (03) :502-506

[7] Metabolically Healthy Obese Women and Functional Capacity [J].

Bouchard, Danielle R. ;

Langlois, Marie-France ;

Brochu, Martin ;

Dionne, Isabelle J. ;

Baillargeon, Jean-Patrice .

METABOLIC SYNDROME AND RELATED DISORDERS, 2011, 9 (03) :225-229

[8] Metabolic Syndrome and Disability: Findings From the Prospective Three-City Study [J].

Carriere, Isabelle ;

Peres, Karine ;

Ancelin, Marie Laure ;

Gourlet, Veronique ;

Berr, Claudine ;

Barberger-Gateau, Pascale ;

Bouillon, Kim ;

Kivimaki, Mika ;

Ritchie, Karen ;

Akbaraly, Tasnime .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2014, 69 (01) :79-86

[9] Metabolic Syndrome and Physical Performance in Elderly Men: The Osteoporotic Fractures in Men Study [J].

Everson-Rose, Susan A. ;

Paudel, Misti ;

Taylor, Brent C. ;

Dam, Tien ;

Cawthon, Peggy Mannen ;

LeBlanc, Erin ;

Strotmeyer, Elsa S. ;

Cauley, Jane A. ;

Stefanick, Marcia L. ;

Barrett-Connor, Elizabeth ;

Ensrud, Kristine E. .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2011, 59 (08) :1376-1384

[10] The Lifestyle Interventions and Independence for Elders Study: Design and Methods [J].

Fielding, Roger A. ;

Rejeski, W. Jack ;

Blair, Steven ;

Church, Tim ;

Espeland, Mark A. ;

Gill, Thomas M. ;

Guralnik, Jack M. ;

Hsu, Fang-Chi ;

Katula, Jeffrey ;

King, Abby C. ;

Kritchevsky, Stephen B. ;

McDermott, Mary M. ;

Miller, Michael E. ;

Nayfield, Susan ;

Newman, Anne B. ;

Williamson, Jeff D. ;

Bonds, Denise ;

Romashkan, Sergei ;

Hadley, Evan ;

Pahor, Marco .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2011, 66 (11) :1226-1237

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