Synthesis, application, and molecular recognition mechanism study of phenylalanine molecularly imprinted polymer

被引：7
|
作者：
Wu, Liqing [1 ]
Gao, Yunhua [1 ]
Wang, Jing [1 ]
机构：
[1] Natl Inst Metrol, Beijing 100013, Peoples R China
来源：
ANALYTICAL LETTERS | 2007年 / 40卷 / 16-18期
基金：
中国国家自然科学基金;
关键词：
molecularly imprinted polymer; hydrogen bond complex; phenylalanine; computer simulation; molecular recognition mechanism;
D O I：
10.1080/00032710701603835
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Phenylalanine molecularly imprinted polymer was synthesized in the presence of triflouroacetic acid. HPLC-MS evaluation showed it had good affinity toward its template among 16 amino acid mixtures. It was used for quantification of phenylalanine in protein hydrolysis solution and in serum without sample pre-treatment. Further study revealed the molecular recognition mechanism involved size exclusion, hydrophobic interaction, and hydrogen bonding interaction. The molecularly imprinted polymer presented here can be used for actual sample analysis and the well characterized recognition mechanism can benefit the design, synthesis, and application of MIP.
引用
收藏
页码：3129 / 3147
页数：19
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