Upregulation of the hypothalamo-neurohypophysial system and activation of vasopressin neurones attenuates hyperalgesia in a neuropathic pain model rat

被引：6

作者：

Baba, Kazuhiko ^{[1
]}

Kawasaki, Makoto ^{[1
]}

Nishimura, Haruki ^{[1
]}

Suzuki, Hitoshi ^{[1
]}

Matsuura, Takanori ^{[1
]}

Ikeda, Naofumi ^{[1
]}

Fujitani, Teruaki ^{[1
]}

Yamanaka, Yoshiaki ^{[1
]}

Tsukamoto, Manabu ^{[1
]}

Ohnishi, Hideo ^{[1
]}

Yoshimura, Mitsuhiro ^{[2
]}

Maruyama, Takashi ^{[2
]}

Sanada, Kenya ^{[2
]}

Sonoda, Satomi ^{[2
]}

Nishimura, Kazuaki ^{[2
]}

Tanaka, Kentaro ^{[2
]}

Onaka, Tatsushi ^{[3
]}

Ueta, Yoichi ^{[2
]}

Sakai, Akinori ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Orthopaed Surg, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan

[2] Univ Occupat & Environm Hlth, Sch Med, Dept Physiol, Kitakyushu, Fukuoka 8078555, Japan

[3] Jichi Med Univ, Dept Physiol, Div Brain & Neurophysiol, Shimotsuke, Tochigi 3290498, Japan

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

基金：

日本学术振兴会;

关键词：

ADJUVANT-INDUCED ARTHRITIS; NUCLEUS RAPHE MAGNUS; ARGININE-VASOPRESSIN; DORSAL RAPHE; INDUCED ANTINOCICEPTION; PATHWAYS; OXYTOCIN; STRESS; PROJECTIONS; MODULATION;

D O I：

10.1038/s41598-022-17477-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Arginine vasopressin (AVP) is a hypothalamic neurosecretory hormone well known as an antidiuretic, and recently reported to be involved in pain modulation. The expression kinetics of AVP and its potential involvement in the descending pain modulation system (DPMS) in neuropathic pain (NP) remains unclear. We investigated AVP expression and its effects on mechanical and thermal nociceptive thresholds using a unilateral spinal nerve ligation (SNL) model. All rats with SNL developed NP. Intensities of enhanced green fluorescent protein (eGFP) in the supraoptic and paraventricular nuclei, median eminence, and posterior pituitary were significantly increased at 7 and 14 days post-SNL in AVP-eGFP rats. In situ hybridisation histochemistry revealed significantly increased AVP mRNA expression at 14 days post-SNL compared with the sham control group. The chemogenetic activation of AVP neurones significantly attenuated mechanical and thermal hyperalgesia with elevated plasma AVP concentration. These analgesic effects were suppressed by pre-administration with V1a receptor antagonist. AVP neurones increased the neuronal activity of serotonergic dorsal raphe, noradrenergic locus coeruleus, and inhibitory interneurones in the spinal dorsal horn. These results suggest that the hypothalamo-neurohypophysial system of AVP is upregulated in NP and activated endogenous AVP exerts analgesic effects via the V1a receptors. AVP neurones may activate the DPMS.

引用

页数：15

共 57 条

[1] Microinjection of arginine vasopressin into the central nucleus of amygdala suppressed nociceptive jaw opening reflex in freely moving rats [J].