The JAM family of junctional adhesion molecules

被引:248
作者
Bazzoni, G [1 ]
机构
[1] Ist Ric Farmacol Mario Negri, Dept Immunol & Cell Biol, I-20157 Milan, Italy
关键词
D O I
10.1016/S0955-0674(03)00104-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Junctional adhesion molecules are a family of glycoproteins characterised by two immunoglobulin folds (V-H- and C-2-type) in the extracellular domain. Junctional adhesion molecule proteins localise to intercellular junctions of polarised endothelial and epithelial cells but can also be expressed on circulating leukocytes and platelets. In addition, they bind several ligands, in both a homophilic and heterophilic manner, and associate with several cytoplasmic partners. All these features represent the likely determinants for the role of junctional adhesion molecule proteins in processes as diverse as junction assembly, leukocyte transmigration and platelet activation.
引用
收藏
页码:525 / 530
页数:6
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