Menstrual and Reproductive Factors, Exogenous Hormone Use, and Gastric Cancer Risk in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition

被引：37

作者：

Duell, Eric J. ^{[1
]}

Travier, Noemie ^{[1
]}

Lujan-Barroso, Leila ^{[1
]}

Boutron-Ruault, M. C. ^{[2
,3
]}

Clavel-Chapelon, F. ^{[2
,3
]}

Palli, Domenico ^{[4
]}

Krogh, Vittorio ^{[5
]}

Mattiello, Amalia ^{[6
]}

Tumino, Rosario ^{[7
]}

Sacerdote, Carlotta ^{[8
,9
]}

Rodriguez, Laudina ^{[10
]}

Sanchez-Cantalejo, Emilio ^{[11
,12
]}

Navarro, Carmen ^{[13
,14
]}

Barricarte, Aurelio ^{[15
,16
]}

Dorronsoro, Miren ^{[17
]}

Khaw, Kay-Tee ^{[18
]}

Wareham, Nicholas ^{[18
]}

Allen, Naomi E. ^{[19
]}

Tsilidis, Konstantinos K. ^{[19
]}

Bueno-de-Mesquita, H. Bas ^{[20
]}

Jeurnink, Suzanne M. ^{[21
]}

Numans, M. E. ^{[22
]}

Peeters, Petra H. M. ^{[22
]}

Lagiou, Pagona ^{[23
]}

Valanou, Elisabeth ^{[23
,24
]}

Trichopoulou, Antonia ^{[23
,24
]}

Kaaks, Rudolf ^{[25
]}

Lukanova-McGregor, Annekatrin ^{[25
]}

Bergman, Manuela M. ^{[26
]}

Boeing, Heiner ^{[26
]}

Manjer, Jonas ^{[27
]}

Lindkvist, Bjorn ^{[28
]}

Stenling, Roger ^{[29
]}

Hallmans, Goran ^{[30
]}

Dahm, Christina C. ^{[31
,32
]}

Overvad, Kim ^{[32
]}

Olsen, Anja ^{[33
]}

Tjonneland, Anne ^{[33
]}

Bakken, Kjersti ^{[34
]}

Lund, Eiliv ^{[34
]}

Jenab, Mazda ^{[35
]}

McCormack, Valerie ^{[35
]}

Rinaldi, Sabina ^{[35
]}

Michaud, Dominique ^{[36
]}

Mouw, Traci ^{[36
]}

Nesi, Gabriella ^{[37
]}

Carneiro, Fatima ^{[38
,39
]}

Riboli, Elio ^{[40
]}

Gonzalez, Carlos A. ^{[1
]}

机构：

[1] Catalan Inst Oncol ICO IDIBELL, Unit Nutr Environm & Canc, Canc Epidemiol Res Program, Barcelona, Spain

[2] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat Hlth, F-94805 Villejuif, France

[3] Paris S Univ, Villejuif, France

[4] Canc Res & Prevent Inst ISPO, Mol & Nutrit Epidemiol Unit, Florence, Italy

[5] Fdn IRCCS Ist Nazl Tumori Milan, Nutrit Epidemiol Unit, Dept Prevent & Prevent Med, Milan, Italy

[6] Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy

[7] Civile MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[8] Ctr Canc Prevent CPO Piedmont, Turin, Italy

[9] Human Genet Fdn HuGeF, Florence, Italy

[10] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[11] Andalusian Sch Publ Hlth, Granada, Spain

[12] CIBER Epidemiol & Salud Publ CIBERESP, Granada, Spain

[13] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[14] CIBER ESP, Murcia, Spain

[15] Navarra Publ Hlth Inst, Pamplona, Spain

[16] CIBERESP, Pamplona, Spain

[17] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa, Gipuzkoa, Spain

[18] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[19] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[20] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[21] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[22] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[23] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[24] Hellen Hlth Fdn, Athens, Greece

[25] German Canc Res Ctr, Dept Canc Epidemiol, D-6900 Heidelberg, Germany

[26] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[27] Lund Univ, Dept Surg, Skane Univ Hosp Malmo, Malmo, Sweden

[28] Sahlgrens Univ Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Gothenburg, Sweden

[29] Umea Univ, Dept Med Biosci, Umea, Sweden

[30] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[31] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[32] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

[33] Inst Canc Epidemiol Diet Canc & Hlth, Danish Canc Soc, Copenhagen, Denmark

[34] Univ Tromso, Dept Community Med, Tromso, Norway

[35] Int Agcy Res Canc, F-69372 Lyon, France

[36] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[37] Univ Florence, Div Anat Pathol, Florence, Italy

[38] Univ Porto IPATIMUP, Inst Mol Pathol & Immunol, Oporto, Portugal

[39] Med Fac HS Joao, Oporto, Portugal

[40] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2010年 / 172卷 / 12期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

estrogens; hormones; menstruation; reproduction; stomach neoplasms; women; UPPER GASTROINTESTINAL-TRACT; POSTMENOPAUSAL WOMEN; REPLACEMENT THERAPY; TREFOIL FACTORS; ESTROGEN; ADENOCARCINOMA; TESTOSTERONE; OOPHORECTOMY; EXPRESSION; ESOPHAGEAL;

D O I：

10.1093/aje/kwq321

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a cohort study of individuals aged 35-70 years from 10 European countries. After a mean follow-up of 8.7 years (through 2004), 181 women for whom complete exposure data were available developed GC. Adjusted hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. All statistical tests were 2-sided. Women who had ovariectomy had a 79% increased risk of GC (based on 25 cases) compared with women who did not (hazard ratio = 1.79, 95% confidence interval: 1.15, 2.78). Total cumulative years of menstrual cycling was inversely associated with GC risk (fifth vs. first quintile: hazard ratio = 0.55, 95% confidence interval: 0.31, 0.98; P(trend) = 0.06). No other reproductive factors analyzed were associated with risk of GC. The results of this analysis provide some support for the hypothesis that endogenous ovarian sex hormones lower GC incidence in women.

引用

页码：1384 / 1393

页数：10

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