Emergence of oxygen- and pyridoxal phosphate-dependent reactions

被引：33

作者：

Hoffarth, Elesha R. ^{[1
]}

Rothchild, Kristina W. ^{[1
]}

Ryan, Katherine S. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC, Canada

来源：

FEBS JOURNAL | 2020年 / 287卷 / 07期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

biosynthesis; insects; monooxygenase; oxidation; oxidative deamination; oxygen; plants; pyridoxal 4 '-phosphate; single-electron transfers; Streptomyces; METHYLDOPA-HYPERSENSITIVE GENE; DOPA DECARBOXYLASE; OXIDATIVE DEAMINATION; ACID DECARBOXYLASE; SIDE REACTIONS; 3,4-DIHYDROXYPHENYLACETALDEHYDE SYNTHASE; FUNCTIONAL-CHARACTERIZATION; ORNITHINE DECARBOXYLASE; GLUTAMATE-DECARBOXYLASE; PSEUDOMONAS-AERUGINOSA;

D O I：

10.1111/febs.15277

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pyridoxal 5'-phosphate (PLP) is an organic cofactor employed by similar to 4% of enzymes. The structure of the PLP cofactor allows for the stabilization of carbanions through resonance. A small number of PLP-dependent enzymes employ molecular oxygen as a cosubstrate. Here, we review the biological roles and possible mechanisms of these enzymes, and we observe that these enzymes are found in multiple protein families, suggesting that reaction with oxygen might have emerged de novo in several protein families and thus could be directed to emerge again through laboratory evolution experiments.

引用

页码：1403 / 1428

页数：26

共 121 条

[41] Escherichia coli acid resistance:: Tales of an amateur acidophile [J].

Foster, JW .

NATURE REVIEWS MICROBIOLOGY, 2004, 2 (11) :898-907

[42] Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196 [J].

Funabashi, Masanori ;

Nonaka, Koichi ;

Yada, Chieko ;

Hosobuchi, Masahiko ;

Masuda, Nobuhisa ;

Shibata, Tomoyuki ;

Van Lanen, Steven G. .

JOURNAL OF ANTIBIOTICS, 2009, 62 (06) :325-332

[43] Plant volatile compounds: Sensory cues for health and nutritional value? [J].

Goff, SA ;

Klee, HJ .

SCIENCE, 2006, 311 (5762) :815-819

[44] NEUROTRANSMITTERS AND NEUROMODULATORS IN THE BASAL GANGLIA [J].

GRAYBIEL, AM .

TRENDS IN NEUROSCIENCES, 1990, 13 (07) :244-254

[45] An Asymmetric Reductase That Intercepts Acyclic Imino Acids Produced in Situ by a Partner Oxidase [J].

Guo, Jin ;

Higgins, Melanie A. ;

Daniel-Ivad, Phillip ;

Ryan, Katherine S. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 141 (31) :12258-12267

[46] Role of aromatic aldehyde synthase in wounding/herbivory response and flower scent production in different Arabidopsis ecotypes [J].

Gutensohn, Michael ;

Klempien, Antje ;

Kaminaga, Yasuhisa ;

Nagegowda, Dinesh A. ;

Negre-Zakharov, Florence ;

Huh, Jung-Hyun ;

Luo, Hongli ;

Weizbauer, Renate ;

Mengiste, Tesfaye ;

Tholl, Dorothea ;

Dudareva, Natalia .

PLANT JOURNAL, 2011, 66 (04) :591-602

[47] Investigating β-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins [J].

Haltli, B ;

Tan, Y ;

Magarvey, NA ;

Wagenaar, M ;

Yin, XH ;

Greenstein, M ;

Hucul, JA ;

Zabriskie, TM .

CHEMISTRY & BIOLOGY, 2005, 12 (11) :1163-1168

[48] Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase [J].

Han, Lanlan ;

Vuksanovic, Nemanja ;

Oehm, Sarah A. ;

Fenske, Tyler G. ;

Schwabacher, Alan W. ;

Silvaggi, Nicholas R. .

BIOCHEMISTRY, 2018, 57 (23) :3252-3264

[49] Streptomyces wadayamensis MppP Is a Pyridoxal 5′-Phosphate-Dependent L-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway [J].

Han, Lanlan ;

Schwabacher, Alan W. ;

Moran, Graham R. ;

Silvaggi, Nicholas R. .

BIOCHEMISTRY, 2015, 54 (47) :7029-7040

[50] Curvulamine, a New Antibacterial Alkaloid Incorporating Two Undescribed Units from a Curvularia Species [J].

Han, Wen Bo ;

Lu, Yan Hua ;

Zhang, Ai Hua ;

Zhang, Gao Fei ;

Mei, Ya Ning ;

Jiang, Nan ;

Lei, Xinxiang ;

Song, Yong Chun ;

Ng, Seik Weng ;

Tan, Ren Xiang .

ORGANIC LETTERS, 2014, 16 (20) :5366-5369

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