Emergence of oxygen- and pyridoxal phosphate-dependent reactions

被引：33

作者：

Hoffarth, Elesha R. ^{[1
]}

Rothchild, Kristina W. ^{[1
]}

Ryan, Katherine S. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC, Canada

来源：

FEBS JOURNAL | 2020年 / 287卷 / 07期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

biosynthesis; insects; monooxygenase; oxidation; oxidative deamination; oxygen; plants; pyridoxal 4 '-phosphate; single-electron transfers; Streptomyces; METHYLDOPA-HYPERSENSITIVE GENE; DOPA DECARBOXYLASE; OXIDATIVE DEAMINATION; ACID DECARBOXYLASE; SIDE REACTIONS; 3,4-DIHYDROXYPHENYLACETALDEHYDE SYNTHASE; FUNCTIONAL-CHARACTERIZATION; ORNITHINE DECARBOXYLASE; GLUTAMATE-DECARBOXYLASE; PSEUDOMONAS-AERUGINOSA;

D O I：

10.1111/febs.15277

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pyridoxal 5'-phosphate (PLP) is an organic cofactor employed by similar to 4% of enzymes. The structure of the PLP cofactor allows for the stabilization of carbanions through resonance. A small number of PLP-dependent enzymes employ molecular oxygen as a cosubstrate. Here, we review the biological roles and possible mechanisms of these enzymes, and we observe that these enzymes are found in multiple protein families, suggesting that reaction with oxygen might have emerged de novo in several protein families and thus could be directed to emerge again through laboratory evolution experiments.

引用

页码：1403 / 1428

页数：26

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