Epitranscriptomics: regulation of mRNA metabolism through modifications

被引：95

作者：

Peer, Eyal ^{[1
,2
,3
]}

Rechavi, Gideon ^{[1
,2
,3
]}

Dominissini, Dan ^{[1
,2
,3
]}

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel

[2] Chaim Sheba Med Ctr, Canc Res Ctr, Tel Hashomer, Israel

[3] Chaim Sheba Med Ctr, Wohl Ctr Translat Med, Tel Hashomer, Israel

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2017年 / 41卷

关键词：

TRANSLATION EFFICIENCY; METHYLATION; N-1-METHYLADENOSINE; N-6-METHYLADENOSINE; N6-METHYLADENOSINE; REVEALS; NUCLEAR; METHYLTRANSFERASE; THERMODYNAMICS; TRANSCRIPTION;

D O I：

10.1016/j.cbpa.2017.10.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular RNAs can be modified post-transcriptionally with dynamic and reversible chemical modifications. These modifications can alter the structure and metabolism of mRNA, but only recent methodological and conceptual advances allowed systematic mapping and functional analysis to unfold the role they play in mRNA biology. Mapping the most common internal mRNA modification, N-6-methyladenosine (m(6)A), paved the way for the deciphering of other types of mRNA modifications, such as N-1-methyladenosine (m(1)A). RNA methylation provides dynamic regulation to the processing, export, translation and stability of mRNA molecules, thereby influencing fundamental biological and pathological processes such as differentiation, cellular response to stress and tumorigenesis. This review summarizes the key methods and the recent discoveries in the field of epitranscriptomics through the prism of post-transcriptional mRNA methylation in eukaryotes.

引用

页码：93 / 98

页数：6

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