Identification of bioactive response in traditional cherries from Portugal

被引：131
作者：
Serra, Ana Teresa [1 ]
Duarte, Rui O. [2 ]
Bronze, Maria R. [1 ,3 ,4 ]
Duarte, Catarina M. M. [1 ,3 ]
机构：
[1] Univ Nova Lisboa, Inst Tecnol Quim & Biol, Estacao Agron Nacl, P-2780157 Oeiras, Portugal
[2] FCT UNL, Dept Quim, REQUIMTE CQFB, P-2829516 Caparica, Portugal
[3] Inst Biol Expt & Tecnol, Estacao Agron Nacl, P-2781901 Oeiras, Portugal
[4] Univ Lisbon, Fac Farm, IMed, P-1649019 Lisbon, Portugal
来源：
FOOD CHEMISTRY | 2011年 / 125卷 / 02期
关键词：
Cherries; Polyphenols; Anthocyanins; Bioactivity; Antioxidant activity; Antiproliferative activity; ANTIOXIDANT ACTIVITY; PHENOLIC PROFILES; SWEET CHERRY; ANTHOCYANINS; CACO-2; WINES; FLAVONOIDS; QUERCETIN; TRANSPORT; EXTRACTS;
D O I：
10.1016/j.foodchem.2010.07.088
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In recent years many studies on cherries have revealed that they are rich sources of bioactive compounds with potential human health benefits. In this work, we evaluated the antioxidant activity and antiproliferative effect in human cancer cells of nine sweet cherries, including two traditional cultivars from Portugal (Saco and Morangao). Results obtained in biological assays, together with the phenolic composition of cherries, were submitted to principal component analysis (PCA) which allowed samples to be grouped in terms of their bioactivity. Saco cherry and two exotic cultivars (Ulster and Lapin) proved to have higher contents of phenolic compounds, highest antioxidant activity and were the most effective in inhibiting human cancer cells derived from colon (HT29) and stomach (MKN45). Correlation of the data obtained showed that anthocyanins were the major contributors to the antioxidant capacity and antiproliferative effect of cherries. Additionally, hydroxycinnamic acids (neochlorogenic acid, chlorogenic acid and p-coumaroylquinic acid), flavan-3-ols (catechin and epicatechin) and flavonols (rutin and quercetin-3-glucoside) also play important roles in protection against oxidative stress. (C) 2010 Published by Elsevier Ltd.
引用
收藏
页码：318 / 325
页数：8
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