Ectopic Recurrence of Arteriovenous Malformation After Radiosurgery: Case Report and Insight Regarding Pathogenesis

被引：5

作者：

Kawashima, Mariko ^{[1
]}

Hasegawa, Hirotaka ^{[1
]}

Kurita, Hiroki ^{[3
,4
]}

Suzuki, Kaima ^{[3
,4
]}

Shin, Masahiro ^{[1
]}

Ikemura, Masako ^{[2
]}

Saito, Nobuhito ^{[1
]}

机构：

[1] Univ Tokyo Hosp, Dept Neurosurg, Tokyo, Japan

[2] Univ Tokyo Hosp, Dept Pathol, Tokyo, Japan

[3] Saitama Med Univ, Int Med Ctr, Dept Cerebrovasc Surg, Saitama, Japan

[4] Saitama Med Univ, Int Med Ctr, Stroke Ctr, Saitama, Japan

来源：

WORLD NEUROSURGERY | 2020年 / 135卷

关键词：

Arteriovenous malformation; Endoglin; Gamma Knife; Stereotactic radiosurgery; HEREDITARY HEMORRHAGIC TELANGIECTASIA; GAMMA-KNIFE SURGERY; ENDOTHELIAL-CELLS; MOYAMOYA-DISEASE; ENDOGLIN CD105; GROWTH-FACTOR; CHILDREN; EXPRESSION; RESECTION; BRAIN;

D O I：

10.1016/j.wneu.2019.11.156

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BACKGROUND: While prior studies reporting de novo arteriovenous malformations after birth are not uncommon, reports of ectopic recurrence of arteriovenous malformation after radiotherapy are scarce. CASE DESCRIPTION: An 8-year-old girl with a ruptured cerebellar arteriovenous malformation was treated with stereotactic radiosurgery. The nidus was completely obliterated 17 months after stereotactic radiosurgery; however, 20 years later she had a rupture of a recurrent nidus that occurred adjacent to the original nidus, accompanied by a radiation-induced cyst. Surgical resection was performed, and subsequent pathologic examination revealed 2 different compartments: a typical nidus and a postirradiated degenerated nidus with an encapsulated hematoma. Immunohistochemical stains showed increased expression of Ki-67 and decreased expression of endoglin in endothelial cells in the recurrent nidus. CONCLUSIONS: Depletion in endoglin may lead to the formation of vessel formations in the presence of angiogenic stimuli. This case serves as a strong reminder of the importance of long-term follow-up after stereotactic radiosurgery, especially for pediatric cases.

引用

页码：63 / 67

页数：5

共 46 条

[1] Reappearance of arteriovenous malformations after complete resection of ruptured arteriovenous malformations: true recurrence or false-negative early postoperative imaging result? [J].