Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers

被引：54

作者：

Chen, Tianfeng ^{[1
]}

Mei, Wen-Jie ^{[1
,2
]}

Wong, Yum-Shing ^{[3
]}

Liu, Jie ^{[1
]}

Liu, Yanan ^{[1
]}

Xie, Huang-Song ^{[2
]}

Zheng, Wen-Jie ^{[1
]}

机构：

[1] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou, Guangdong, Peoples R China

[3] Chinese Univ Hong Kong, Dept Biol, Hong Kong, Hong Kong, Peoples R China

来源：

MEDCHEMCOMM | 2010年 / 1卷 / 01期

关键词：

DNA-BINDING; P53; PHOSPHORYLATION; CELLULAR UPTAKE; CELLS; CYTOTOXICITY;

D O I：

10.1039/c0md00060d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of chiral ruthenium polypyridyl complexes have been synthesized and evaluated for their in vitro anticancer activities. A-[Ru(bpy)(2)(o-tFMPIP)]Cl-2 center dot 3H(2)O was identified as a novel mitochondria-targeted complex, which was able to induce mitochondria-mediated apoptosis in melanoma A375 cells through regulation of Bcl-2 family members and activation of caspases.

引用

页码：73 / 75

页数：3

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