[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy

被引：189

作者：

Gerhard, A

Banati, RB

Goerres, GB

Cagnin, A

Myers, R

Gunn, RN

Turkheimer, F

Good, CD

Mathias, CJ

Quinn, N

Schwarz, J

Brooks, DJ

机构：

[1] Hammersmith Hosp, Imaging Res Solut Ltd, London W12 0NN, England

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, MRC, Ctr Clin Sci, London, England

[3] Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Neurosci, London, England

[4] Univ Zurich, Div Nucl Med, CH-8006 Zurich, Switzerland

[5] Univ Padua, Dept Neurol & Psychiat, I-35100 Padua, Italy

[6] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada

[7] Inst Neurol, London WC1N 3BG, England

[8] Univ Leipzig, Dept Neurol, Leipzig, Germany

来源：

NEUROLOGY | 2003年 / 61卷 / 05期

关键词：

D O I：

10.1212/01.WNL.0000078192.95645.E6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Microglia, the brain's intrinsic macrophages, bind (R)-PK11195 when activated by neuronal injury. The authors used [C-11](R)-PK11195 PET to localize in vivo microglial activation in patients with multiple system atrophy (MSA). Increased [C-11](R)-PK11195 binding was primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an indicator of disease activity, [C-11](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA.

引用

页码：686 / 689

页数：4

共 10 条

[1] PK ('peripheral benzodiazepine') - Binding sites in the CNS indicate early and discrete brain lesions: Microautoradiographic detection of [H-3]PK11195 binding to activated microglia [J].