Omega-3 PUFA attenuate mice myocardial infarction injury by emerging a protective eicosanoid pattern

被引：8

作者：

Fang, Xuan ^{[1
]}

Cai, Wenbin ^{[2
,3
]}

Cheng, Qian ^{[2
,3
]}

Ai, Ding ^{[2
,3
]}

Wang, Xian ^{[1
]}

Hammock, Bruce D. ^{[4
,5
]}

Zhu, Yi ^{[1
,2
,3
]}

Zhang, Xu ^{[1
,2
,3
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing, Peoples R China

[2] Tianjin Med Univ, Tianjin Key Lab Metab Dis, Tianjin, Peoples R China

[3] Tianjin Med Univ, Dept Physiol, Tianjin, Peoples R China

[4] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA

[5] Univ Calif Davis, Ctr Comprehens Canc, Davis, CA 95616 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2018年 / 139卷

基金：

中国国家自然科学基金;

关键词：

Omega-3; PUFA; Eicosanoid; Myocardial infarction; Metabolomics; POLYUNSATURATED FATTY-ACIDS; CYTOCHROME-P450; ENZYMES; PROSTAGLANDIN E-2; DISEASE; OMEGA-3-FATTY-ACIDS; METABOLISM; PREVENTION; GUIDELINES; CORONARY; DELETION;

D O I：

10.1016/j.prostaglandins.2018.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation is a recommended preventive approach against cardiovascular diseases, but its mechanism of protection against myocardial infarction (MI) injury is not fully understood. Eicosanoid metabolomics demonstrated an abnormal eicosanoid profile was in the plasma of mice receiving MI surgery. 19,20-EDP, 17,18-EEQ, 14,15-EET and 9,10-EpOME were decreased, and PGE(2) was increased by the surgery. N-3 PUFA-rich diets feeding or transgene of Fat-1 shifted the eicosanoid profile to an n-3 PUFA dominant style and attenuated the myocardial infarction injury. Multiple logistic regression analysis suggested the degree of MI injury was related with an eicosanoid pattern, composed by eicosanoids derived from both n-3 and n-6 PUFA in the three enzymatic pathways. These results suggested the benefits of n-3 PUFA on MI was achieved synergistically.

引用

页码：1 / 9

页数：9

共 24 条

[1] Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids [J].

Arnold, Cosima ;

Markovic, Marija ;

Blossey, Katrin ;

Wallukat, Gerd ;

Fischer, Robert ;

Dechend, Ralf ;

Konkel, Anne ;

von Schacky, Clemens ;

Luft, Friedrich C. ;

Muller, Dominik N. ;

Rothe, Michael ;

Schunck, Wolf-Hagen .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (43) :32720-32733

[2] Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion [J].

Bagga, D ;

Wang, L ;

Farias-Eisner, R ;

Glaspy, JA ;

Reddy, ST .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1751-1756

[3] Spectrum evaluation-assisted eicosanoid metabolomics for global eicosanoid profiling in human vascular endothelial cells [J].

Bao, Qiankun ;

Liu, Yajin ;

Song, Hao ;

Yang, Nan ;

Ai, Ding ;

Zhu, Yi ;

Zhang, Xu .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018, 45 (01) :98-108

[4] Specialized pro-resolving mediators: endogenous regulators of infection and inflammation [J].

Basil, Maria C. ;

Levy, Bruce D. .

NATURE REVIEWS IMMUNOLOGY, 2016, 16 (01) :51-67

[5]

Benjamin EJ, 2018, CIRCULATION, V137, pE67, DOI [10.1161/CIR.0000000000000558, 10.1161/CIR.0000000000000485, 10.1161/CIR.0000000000000530]

[6] European guidelines on cardiovascular disease prevention in clinical practice -: Third joint task force of European and other societies on cardiovascular disease prevention in clinical practice [J].

De Backer, G ;

Ambrosioni, E ;

Borch-Johnsen, K ;

Brotons, C ;

Cifkova, R ;

Dallongeville, J ;

Ebrahim, S ;

Faergeman, O ;

Graham, I ;

Mancia, G ;

Cats, VM ;

Orth-Gomér, K ;

Perk, J ;

Pyörälä, K ;

Rodicio, JL ;

Sans, S ;

Sansoy, V ;

Sechtem, U ;

Silber, S ;

Thomsen, T ;

Wood, D .

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, 2003, 10 (04) :S1-S10

[7] DRUG THERAPY n-3 Fatty Acids in Cardiovascular Disease [J].

De Caterina, Raffaele .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (25) :2439-2450

[8] Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction [J].

Degousee, Norbert ;

Fazel, Shafie ;

Angoulvant, Denis ;

Stefanski, Eva ;

Pawelzik, Sven-Christian ;

Korotkova, Marina ;

Arab, Sara ;

Liu, Peter ;

Lindsay, Thomas F. ;

Zhuo, Sun ;

Butany, Jagdish ;

Li, Ren-Ke ;

Audoly, Laurent ;

Schmidt, Ronald ;

Angioni, Carlo ;

Geisslinger, Gerd ;

Jakobsson, Per-Johan ;

Rubin, Barry B. .

CIRCULATION, 2008, 117 (13) :1701-1710

[9] 18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling [J].

Endo, Jin ;

Sano, Motoaki ;

Isobe, Yosuke ;

Fukuda, Keiichi ;

Kang, Jing X. ;

Arai, Hiroyuki ;

Arita, Makoto .

JOURNAL OF EXPERIMENTAL MEDICINE, 2014, 211 (08) :1673-1687

[10] 17(R),18(S)-Epoxyeicosatetraenoic Acid, a Potent Eicosapentaenoic Acid (EPA) Derived Regulator of Cardiomyocyte Contraction: Structure-Activity Relationships and Stable Analogues [J].

Falck, John R. ;

Wallukat, Gerd ;

Puli, Narender ;

Goli, Mohan ;

Arnold, Cosima ;

Konkel, Anne ;

Rothe, Michael ;

Fischer, Robert ;

Mueller, Dominik N. ;

Schunck, Wolf-Hagen .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (12) :4109-4118

← 1 2 3 →