Selective Cell Control by Surface Structuring for Orthopedic Applications

被引：33

作者：

Fadeeva, E. ^{[1
]}

Schlie, S. ^{[1
]}

Koch, J. ^{[1
]}

Chichkov, B. N. ^{[1
]}

机构：

[1] Laser Zentrum Hannover eV, D-30419 Hannover, Germany

来源：

JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY | 2010年 / 24卷 / 13-14期

关键词：

Femtosecond laser fabrication; titanium; surface topography; contact angle; fibroblast; osteoblast; TITANIUM IMPLANT; FEMTOSECOND; PICOSECOND;

D O I：

10.1163/016942410X508000

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

In this work we present an in vitro study of the influence of two types of femtosecond laser generated topographies on a titanium surface - grooves with different periodicities and "lotus-like" structures - on the behavior of human fibroblast and MG-63 osteoblast cells. We show that anisotropy in wetting of groove structures correlates well with contact guidance of cells. The "lotus-like" structured titanium surfaces show superhydrophobic properties and influence differentially osteoblast and fibroblast adhesion and growth. The proliferation of fibroblast cells is inhibited, whereas the proliferation of osteoblast cells is promoted. This technique for cell specific control offers promising perspectives in fabrication of new functionalized implants. (C) Koninklijke Brill NV, Leiden, 2010

引用

页码：2257 / 2270

页数：14

共 35 条

[1] Cell-matrix contact structures [J].