Swine Influenza H1N1 Virus Induces Acute Inflammatory Immune Responses in Pig Lungs: a Potential Animal Model for Human H1N1 Influenza Virus
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作者:
Khatri, Mahesh
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Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Khatri, Mahesh
[1
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Dwivedi, Varun
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Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Dwivedi, Varun
[1
]
Krakowka, Steven
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Ohio State Univ, Coll Vet Med, Dept Vet Biosci, Columbus, OH 43210 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Krakowka, Steven
[2
]
Manickam, Cordelia
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Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Manickam, Cordelia
[1
]
Ali, Ahmed
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Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Ali, Ahmed
[1
]
Wang, Leyi
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Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Wang, Leyi
[1
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Qin, Zhuoming
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Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Shandong Acad Agr Sci, Inst Poultry Sci, Jinan 250023, Peoples R ChinaOhio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Qin, Zhuoming
[1
,3
]
Renukaradhya, Gourapura J.
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Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Ohio State Univ, Coll Vet Med, Dept Vet Prevent Med, Columbus, OH 43210 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Renukaradhya, Gourapura J.
[1
,4
]
Lee, Chang-Won
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Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Ohio State Univ, Coll Vet Med, Dept Vet Prevent Med, Columbus, OH 43210 USAOhio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
Lee, Chang-Won
[1
,4
]
机构:
[1] Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
[2] Ohio State Univ, Coll Vet Med, Dept Vet Biosci, Columbus, OH 43210 USA
[3] Shandong Acad Agr Sci, Inst Poultry Sci, Jinan 250023, Peoples R China
[4] Ohio State Univ, Coll Vet Med, Dept Vet Prevent Med, Columbus, OH 43210 USA
Pigs are capable of generating reassortant influenza viruses of pandemic potential, as both the avian and mammalian influenza viruses can infect pig epithelial cells in the respiratory tract. The source of the current influenza pandemic is H1N1 influenza A virus, possibly of swine origin. This study was conducted to understand better the pathogenesis of H1N1 influenza virus and associated host mucosal immune responses during acute infection in humans. Therefore, we chose a H1N1 swine influenza virus, Sw/OH/24366/07 (SwIV), which has a history of transmission to humans. Clinically, inoculated pigs had nasal discharge and fever and shed virus through nasal secretions. Like pandemic H1N1, SwIV also replicated extensively in both the upper and lower respiratory tracts, and lung lesions were typical of H1N1 infection. We detected innate, proinflammatory, Th1, Th2, and Th3 cytokines, as well as SwIV-specific IgA antibody in lungs of the virus-inoculated pigs. Production of IFN-gamma by lymphocytes of the tracheobronchial lymph nodes was also detected. Higher frequencies of cytotoxic T lymphocytes, gamma delta T cells, dendritic cells, activated T cells, and CD4(+) and CD8(+) T cells were detected in SwIV-infected pig lungs. Concomitantly, higher frequencies of the immunosuppressive T regulatory cells were also detected in the virus-infected pig lungs. The findings of this study have relevance to pathogenesis of the pandemic H1N1 influenza virus in humans; thus, pigs may serve as a useful animal model to design and test effective mucosal vaccines and therapeutics against influenza virus.
机构:
Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Chan, Jennifer
Regner, Matthias
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Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Regner, Matthias
Lobigs, Mario
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Inst Med & Vet Sci, Adelaide, SA 5000, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Lobigs, Mario
Koskinen, Aulikki
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Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Koskinen, Aulikki
Kok, Tuckweng
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Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Kok, Tuckweng
Manavis, Jim
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Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Manavis, Jim
Li, Peng
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Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Li, Peng
Mullbacher, Arno
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Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
机构:
Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Chan, Jennifer
Regner, Matthias
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机构:
Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Regner, Matthias
Lobigs, Mario
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机构:
Inst Med & Vet Sci, Adelaide, SA 5000, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Lobigs, Mario
Koskinen, Aulikki
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机构:
Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Koskinen, Aulikki
Kok, Tuckweng
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机构:
Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Kok, Tuckweng
Manavis, Jim
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Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Manavis, Jim
Li, Peng
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Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
Li, Peng
Mullbacher, Arno
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Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia