Insulin-induced gene A new regulator in lipid metabolism

被引：99
作者：
Dong Xiao-Ying [1 ]
Tang Sheng-Qiu [1 ]
机构：
[1] Shaoguan Univ, Coll Yingdong Agr Sci & Engn, Shaoguan 512005, Peoples R China
来源：
PEPTIDES | 2010年 / 31卷 / 11期
关键词：
Insigs; SCAP; HMG-CoA reductase; Cholesterol metabolism; Lipogenesis; Glucose homeostasis; Disease; CLEAVAGE-ACTIVATING PROTEIN; STEROL-SENSING DOMAIN; ELEMENT-BINDING PROTEIN; HMG-COA REDUCTASE; WHITE ADIPOSE-TISSUE; COENZYME-A REDUCTASE; FATTY-ACID SYNTHESIS; HAMSTER OVARY CELLS; ENDOPLASMIC-RETICULUM; PROTEASOMAL DEGRADATION;
D O I：
10.1016/j.peptides.2010.07.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Insulin-induced genes (Insigs) including Insig-1 and Insig-2 are proteins that mediate sterol regulation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) Insigs perform distinct tasks in the regulation of these effectors they promote the endoplasmic reticulum (ER) retention of SCAP but ubiquitin-mediated degradation of HMG-CoA reductase Through these activities Insig-1 and Insig-2 influence cholesterol metabolism lipogenesis and glucose homeostasis in diverse tissues such as adipose tissue and liver In this article we focus on the functions expression and regulation gene polymorphisms of Insigs and their deficiency with diseases Crown Copyright (C) 2010 Published by Elsevier Inc All rights reserved
引用
收藏
页码：2145 / 2150
页数：6
相关论文
共 83 条
[1]   Cholesterol-induced conformational change in SCAP enhanced by insig proteins and mimicked by cationic amphiphiles [J].
Adams, CM ;
Goldstein, JL ;
Brown, MS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :10647-10652
[2]   Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and insigs [J].
Adams, CM ;
Reitz, J ;
De Brabander, JK ;
Feramisco, JD ;
Li, L ;
Brown, MS ;
Goldstein, JL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (50) :52772-52780
[3]   Insig: a significant integrator of nutrient and hormonal signals [J].
Attie, AD .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (08) :1112-1114
[4]   A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood [J].
Brown, MS ;
Goldstein, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11041-11048
[5]   Insig Regulates HMG-CoA Reductase by Controlling Enzyme Phosphorylation in Fission Yeast [J].
Burg, John S. ;
Powell, David W. ;
Chai, Raymond ;
Hughes, Adam L. ;
Link, Andrew J. ;
Espenshade, Peter J. .
CELL METABOLISM, 2008, 8 (06) :522-531
[6]   Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels [J].
Cervino, AC ;
Li, GY ;
Edwards, S ;
Zhu, J ;
Laurie, C ;
Tokiwa, G ;
Lum, PY ;
Wang, S ;
Castellini, LW ;
Lusis, AJ ;
Carlson, S ;
Sachs, AB ;
Schadt, EE .
GENOMICS, 2005, 86 (05) :505-517
[7]   In vivo regulation of SREBP-1c in skeletal muscle:: effects of nutritional status, glucose, insulin, and leptin [J].
Commerford, SR ;
Peng, L ;
Dubé, JJ ;
O'Doherty, RM .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 287 (01) :R218-R227
[8]   Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis [J].
Engelking, LJ ;
Kuriyama, H ;
Hammer, RE ;
Horton, JD ;
Brown, MS ;
Goldstein, JL ;
Liang, G .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (08) :1168-1175
[9]   Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin [J].
Engelking, Luke J. ;
Evers, Bret M. ;
Richardson, James A. ;
Goldstein, Joseph L. ;
Brown, Michael S. ;
Liang, Guosheng .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (09) :2356-2365
[10]   Regulation of sterol synthesis in eukaryotes [J].
Espenshade, Peter J. ;
Hughes, Adam L. .
ANNUAL REVIEW OF GENETICS, 2007, 41 :401-427
123456789