New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity

被引：56
作者：
Chimichi, S
Boccalini, M
Cosimelli, B
Dall'Acqua, F
Viola, G
机构：
[1] Dipartimento Chim Organ U Schiff, I-50019 Sesto Fno, Firenze, Italy
[2] Univ Naples Federico II, Dipartimento Chim Farmaceut & Tossicol, I-80131 Naples, Italy
[3] Dipartimento Sci Farmaceut, I-35131 Padua, Italy
来源：
TETRAHEDRON | 2003年 / 59卷 / 28期
关键词：
D O I：
10.1016/S0040-4020(03)00776-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient route to new 3(2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived human cell lines in comparison to the natural compound geiparvarin. The structure activity relationship indicated that the maximum in vitro antiproliferative activity correlates with the presence of a heterocyclic ring on the ethenyl moiety. (C) 2003 Elsevier Science Ltd. All rights reserved.
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收藏
页码：5215 / 5223
页数：9
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