Dynamics of drug-resistant HIV-1 in plasma and peripheral blood cells in patients during and after enfuvirtide therapy

被引：9
|
作者：
Poveda, Eva
Briz, Veronica
Paraskevis, Dimitrios
Barreiro, Pablo
Hatzakis, Angelos
Soriano, Vincent
机构：
[1] Hosp Carlos III, Dept Infect Dis, Madrid 28029, Spain
[2] Univ Athens, Sch Med, Dept Infect Dis, GR-11527 Athens, Greece
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2007年 / 23卷 / 09期
关键词：
D O I：
10.1089/aid.2006.0287
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Genetic analysis of HIV-1 gp41 in plasma and peripheral blood mononuclear cell (PBMC) compartments was performed longitudinally in 10 HIV-infected patients treated with enfuvirtide. The appearance of enfuvirtide resistance mutations in PBMCs (DNA) generally occurred after (from 23 to 157 weeks) being recognizable in plasma (RNA). The disappearance of drug-resistant HIV-1 mutations to enfuvirtide in seven patients who discontinued the drug was directly dependent of the exposure time failing enfuvirtide, being associated mainly with the selection of secondary/compensatory mutations recognizable in proviral DNA.
引用
收藏
页码：1078 / 1082
页数：5
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