Novel self-assembled pH-responsive biomimetic nanocarriers for drug delivery

被引：20
作者：
Wu, Minming [1 ]
Cao, Zhaoyu [1 ]
Zhao, Yunfei [1 ]
Zeng, Rong [1 ]
Tu, Mei [1 ]
Zhao, Jianhao [1 ]
机构：
[1] Jinan Univ, Dept Mat Sci & Engn, Coll Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 64卷
基金：
中国国家自然科学基金;
关键词：
Biomimetic; pH-responsive; Chitosan; Nanocarriers; Controlled release; COMPLEMENT ACTIVATION; CHITOSAN DERIVATIVES; CARBON NANOTUBES; GENE DELIVERY; QUERCETIN; MICELLES; NANOPARTICLES; MEMBRANE; SYSTEM; BLOCK;
D O I：
10.1016/j.msec.2016.03.099
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Novel pH-responsive biodegradable biomimetic nanocarriers were prepared by the self-assembly of N-acetyl-L-histidine-phosphorylcholine-chitosan conjugate (NAcHis-PCCs), which was synthesized via Atherton-Todd reaction to couple biomembrane-like phosphorylcholine (PC) groups, and N,N'-carbonyldiimidazole (MI) coupling reaction to link pH-responsive N-acetyl-L-histidine (NAcHis) moieties to chitosan. In vitro biological assay revealed that NAcHis-PCCs nanoparticles had excellent biocompatibility to avoid adverse biological response mainly owing to their biomimetic PC shell, and DLS results confirmed their pH-responsive behavior in acidic aqueous solution (pH <= 6.0). Quercetin (QUE), an anti-inflammatory, antioxidant and potential anti-tumor hydrophobic drug, was effectively loaded in NAcHis-PCCs nanocarriers and showed a pH-triggered release behavior with the enhanced QUE release at acidic pH 5.5 compared to neutral pH 7.4. The results indicated that pH responsive biomimetic NAcHis-PCCs nanocarriers might have great potential for site-specific delivery to pathological acidic microenvironment avoiding unfavorable biological response. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：346 / 353
页数：8
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