Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea)

被引：43

作者：

Thejass, P. ^{[1
]}

Kuttan, G. ^{[1
]}

机构：

[1] Amala Canc Res Ctr, Dept Immunol, Trichur 680555, Kerala State, India

来源：

PHYTOMEDICINE | 2007年 / 14卷 / 7-8期

关键词：

sulforaphane; immunomodulation; phagocytosis; tumour necrosis factor-alpha;

D O I：

10.1016/j.phymed.2006.09.013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effect of Sulforaphane on the immune system was studied using BALB/c mice. Intraperitoneal administration of five doses of Sulforaphane (500 mu g/dose/animal/day) was found to enhance the total WBC count (12,950 cells/mm(3)) on 9th day. Bone marrow cellularity (23 x 10(6) CellS/femur) and number of alpha-esterase positive cells (1346.66/4000 cells) were also increased by the administration of Sulforaphane. Treatment with Sulforaphane along with the antigen, sheep red blood cells (SRBC), produced an enhancement in the circulating antibody titre and the number of plaque forming cells (PFC) in the spleen. Maximum number of PFC (315.83 PFC/10(6) spleen cells) was obtained on the 6th day. Administration of Sulforaphane also showed an enhancement in the phagocytic activity of peritoneal macrophages. Moreover administration of Sulforaphane significantly reduced the elevated level of TNF-alpha production by LPS stimulated macrophages. These results indicate the immunomodulatory activity of Sulforaphane. (c) 2006 Elsevier GmbH. All rights reserved.

引用

页码：538 / 545

页数：8

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