Cytokine profiles in children with acute intussusception in South Africa

被引：0

作者：

Bessey, Theresa K. ^{[1
]}

Parashar, Umesh D. ^{[1
]}

Tate, Jacqueline E. ^{[1
]}

Madhi, Shabir A. ^{[2
]}

Jiang, Baoming ^{[1
]}

Groome, Michelle J. ^{[2
]}

机构：

[1] Natl Ctr Immunizat & Resp Dis, Ctr Dis Control & Prevent CDC, Div Viral Dis, Atlanta, GA USA

[2] Univ Witwatersrand, Fac Hlth Sci, Wits Vaccines & Infect Dis Analyt Res Unit, South African Med Res Council, Johannesburg, South Africa

来源：

CYTOKINE | 2021年 / 146卷

基金：

比尔及梅琳达.盖茨基金会;

关键词：

Intussusception; Surveillance; C-reactive protein; Pro-inflammatory cytokines; Rotavirus vaccination; Acute Gastroenteritis; IFN-gamma; ROTAVIRUS INFECTION; VACCINATION; IMMUNIZATION; INFLAMMATION; ASSOCIATION; REGULATOR; EFFICACY; VACCINES; INFANTS; SAFETY;

D O I：

10.1016/j.cyto.2021.155639

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Serum specimens of children hospitalized with acute intussusception (IS; n = 407) were analyzed for various pro and anti-inflammatory cytokines to identify host markers specifically for IS compared to other surgical conditions (n = 235) or acute gastroenteritis (AGE; n = 68) in a cross-sectional study design. We showed that children with IS had elevated levels of pro-inflammatory cytokines IFN-gamma, TNF-alpha, MIP-1 beta, IL-1 beta, IL-2, IL-6, IL-7, IL-8, and IL-17 as well as anti-inflammatory cytokines IL-1RA, IL-4, IL-5, and IL-13 compared to those admitted with surgical conditions or AGE symptoms, indicating these cytokines as markers for IS. In addition, we showed an increase in C-reactive protein (CRP) levels in children with IS. This study is the first to show a broad cytokine profile and identify cytokine markers in children with IS.

引用

页数：6

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