Vasoactive intestinal peptide: a novel neurotrophic factor

被引：5
|
作者：
Gressens, P
机构：
[1] Hop Robert Debre, Serv Neurol Pediat, F-75019 Paris, France
[2] Hop Robert Debre, INSERM, CRI 97 01, F-75019 Paris, France
来源：
ARCHIVES DE PEDIATRIE | 1998年 / 5卷 / 06期
关键词：
brain; developmental biology; receptors; sensory; vasoactive intestinal peptide;
D O I：
10.1016/S0929-693X(98)80174-7
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Vasoactive intestinal peptide (VIP) is a 28-amino acid neuropeptide with potent growth-related actions on dissociated neural cells. In recent years its role in brain development was been elucidated: VIP has been shown to be a regulator of early neurodevelopment and embryonic growth, a stimulator of neocortical astrocytogenesis and a neuroprotective molecule against excitotoxic and other neurotoxic substances. Thus VIP appears as a fundamental regulator of brain growth and development, and a potent neuroprotective agent possibly involved in pathological processes such as microcephalies and some neurological impairments observed in very premature babies. Similarly, VIP and VIP derivatives could represent a new avenue in the search of therapeutics for excitotoxic lesions of the developing brain. (C) 1998, Elsevier, Paris.
引用
收藏
页码：654 / 660
页数：7
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