Synergistic effect of endothelin-1 and serotonin in rabbit platelets:: Effect on tyrosine phosphorylation

被引：2
作者：
Liras, A
Catalán, RE
Martínez, AM
机构：
[1] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, Dept Biol Mol, E-28049 Madrid, Spain
[2] Univ Complutense Madrid, Fac Quim, Dept Bioquim & Biol Mol 1, ES-28040 Madrid, Spain
来源：
THROMBOSIS RESEARCH | 2000年 / 100卷 / 04期
关键词：
endothelin-1; serotonin; tyrosine phosphorylation; rabbit platelets; serotonergic effects; partial agonism;
D O I：
10.1016/S0049-3848(00)00328-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effect of endothelin-1 on protein tyrosine phosphorylation was partially inhibited in rabbit platelets, in the presence of ET(A) receptor antagonists. After a sarafotoxin S6c treatment (an ET(B) receptor agonist), a minor effect, compared with the endothelin-1 effect, was found. On the other hand, pre-treatment of platelets with endothelin-1 resulted in an enhancementin serotonin-promoted protein tyrosine phosphorylation. Moreover, in rabbit platelet membrane, endothelin-1 induces a concentration-dependent serotonin binding enhancement and inhibition of its internalization. Thus, endothelin-1 may act as a partial agonist with serotonin through A and B components for a putative endothelin-1 receptor in rabbit platelets.
引用
收藏
页码：325 / 331
页数：7
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