Palladium-Catalyzed Carbo-Aminative Cyclization of 1,6-Enynes: Access to Napthyridinone Derivatives

被引：16

作者：

Babu, Undamatla Suri ^{[1
,2
]}

Singam, Maneesh Kumar Reddy ^{[1
,2
]}

Kumar, Muniganti Naveen ^{[1
,2
]}

Nanubolu, Jagadeesh Babu ^{[2
,3
]}

Reddy, Maddi Sridhar ^{[1
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, India

[2] Acad Sci & Innovat Res, Ghaziabad 201002, India

[3] CSIR, IICT, Analyt Dept, Hyderabad 500007, India

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 08期

关键词：

CASCADE REACTIONS; GAMMA-LACTAMS; REDUCTIVE CYCLIZATION; CYCLOISOMERIZATION; CONSTRUCTION; RHODIUM; HETEROCYCLES; N-ENYNES; ENYNES; TOOL;

D O I：

10.1021/acs.orglett.2c00088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,6-Enynes have recently stimulated enormous attention toward paving the way to unique cascade cyclizations offering complex cyclic motifs from linear substrates. We describe herein a general approach to napthyridinones via the Pd-catalyzed annulation of 1,6-enynes with 2-iodoanilines. This protocol represents a rare carbo-aminative annulative cyclization via the 6-endo-trig mode, subduing the well-documented exo-trig/dig cyclizations. The regioselective aryl palladation of alkyne followed by Heck-type intramolecular this cascade.

引用

页码：1598 / 1603

页数：6

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