Intrinsic mechanisms of poly(ADP-ribose) neurotoxicity: Three hypotheses

被引：24
作者：
Chiarugi, A [1 ]
机构：
[1] Univ Florence, Dept Pharmacol, I-50139 Florence, Italy
来源：
NEUROTOXICOLOGY | 2005年 / 26卷 / 05期
关键词：
neurodegeneration; PARP; PARG; poly(ADP-ribose); gene expression; brain ischemia;
D O I：
10.1016/j.neuro.2005.01.012
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Poly(ADP-ribose) (PAR) is a branched and negatively charged polymeric macromolecule formed by poly(ADP-ribose) polymerases. Targeting of PAR onto acceptor proteins affects their functioning and regulates cellular homeostasis. A large body of evidence demonstrates that increased neo-formation of PAR has a crucial role in neurodegeneration. Consistently, strategies aimed at reducing PAR synthesis are of therapeutic relevance to treatment of several experimental neurodegenerative diseases. However, how PAR causes neuronal death is still elusive. This review provides all appraisal of the possible molecular mechanisms underlying PAR neurotoxicity, highlighting the pleiotypic effects of the polymer on neural cells exposed to different stressful conditions. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：847 / 855
页数：9
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