Synthesis and properties of several Betti bases as potential drugs

The aim of the present study was to synthesize several Betti bases by a modified Betti reaction, to develop analytical methods for the quantitative determination and testing the microbiological and antioxidant activities. For the modification of the Betti reaction we used primary heterocyclic amine, aromatic aldehydes, 8-quinolinol and halogeno-substituted aromatic aldehydes. Betti bases were obtained at yield 80-98% and characterized by elemental analysis and NMR spectra. The applied analytical methods for quantitative determination of the studied Betti bases offered short analysis time, high precision, high linearity and satisfactory limit of detection ( LOD) and limit of quantification ( LOQ) values. The microbiological activity of studied Betti bases was tested against 23 test strains pathogenic microorganisms ( different gram positive and gram negative). The microbiological screening proved their selective microbiological activity. According to the EPR study, the Betti bases possess radical structure and are likely to exhibit antioxidant activity. We assume that the potential of the presented Betti bases as a pharmacological compound is promising.