Bile acids in immunity: Bidirectional mediators between the host and the microbiota

被引：37

作者：

Godlewska, Urszula ^{[1
]}

Bulanda, Edyta ^{[1
]}

Wypych, Tomasz P. P. ^{[1
]}

机构：

[1] Polish Acad Sci, Nencki Inst Expt Biol, Lab Host Microbiota Interact, Warsaw, Poland

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

bile acids; microbial metabolites; immunity; intestinal inflammation; host-microbiota interactions; NUCLEAR RECEPTOR; IDENTIFICATION; CHOLESTEROL; ACTIVATION; MECHANISM; BACTERIA; COLITIS; LIGANDS; PATHWAY;

D O I：

10.3389/fimmu.2022.949033

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this interplay. As host-derived compounds, they display bacteriostatic properties and affect the survival and growth of the members of the microbial community. As microbiota-modified metabolites, they further influence the microbiota composition and, in parallel, modulate the immunity of the host. Here, we provide a comprehensive overview of the mechanisms behind this unique dialogue and discuss how we can harness bile acids to treat intestinal inflammation.

引用

页数：8

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