Bile acids in immunity: Bidirectional mediators between the host and the microbiota

被引：37

作者：

Godlewska, Urszula ^{[1
]}

Bulanda, Edyta ^{[1
]}

Wypych, Tomasz P. P. ^{[1
]}

机构：

[1] Polish Acad Sci, Nencki Inst Expt Biol, Lab Host Microbiota Interact, Warsaw, Poland

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

bile acids; microbial metabolites; immunity; intestinal inflammation; host-microbiota interactions; NUCLEAR RECEPTOR; IDENTIFICATION; CHOLESTEROL; ACTIVATION; MECHANISM; BACTERIA; COLITIS; LIGANDS; PATHWAY;

D O I：

10.3389/fimmu.2022.949033

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this interplay. As host-derived compounds, they display bacteriostatic properties and affect the survival and growth of the members of the microbial community. As microbiota-modified metabolites, they further influence the microbiota composition and, in parallel, modulate the immunity of the host. Here, we provide a comprehensive overview of the mechanisms behind this unique dialogue and discuss how we can harness bile acids to treat intestinal inflammation.

引用

页数：8

共 49 条

[1] The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis [J].

Biagioli, Michele ;

Carino, Adriana ;

Cipriani, Sabrina ;

Francisci, Daniela ;

Marchiano, Silvia ;

Scarpelli, Paolo ;

Sorcini, Daniele ;

Zampella, Angela ;

Fiorucci, Stefano .

JOURNAL OF IMMUNOLOGY, 2017, 199 (02) :718-733

[2] Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile [J].

Buffie, Charlie G. ;

Bucci, Vanni ;

Stein, Richard R. ;

McKenney, Peter T. ;

Ling, Lilan ;

Gobourne, Asia ;

No, Daniel ;

Liu, Hui ;

Kinnebrew, Melissa ;

Viale, Agnes ;

Littmann, Eric ;

van den Brink, Marcel R. M. ;

Jenq, Robert R. ;

Taur, Ying ;

Sander, Chris ;

Cross, Justin R. ;

Toussaint, Nora C. ;

Xavier, Joao B. ;

Pamer, Eric G. .

NATURE, 2015, 517 (7533) :205-U207

[3] Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells [J].

Campbell, Clarissa ;

McKenney, Peter T. ;

Konstantinovsky, Daniel ;

Isaeva, Olga I. ;

Schizas, Michail ;

Verter, Jacob ;

Mai, Cheryl ;

Jin, Wen-Bing ;

Guo, Chun-Jun ;

Violante, Sara ;

Ramos, Ruben J. ;

Cross, Justin R. ;

Kadaveru, Krishna ;

Hambor, John ;

Rudensky, Alexander Y. .

NATURE, 2020, 581 (7809) :475-+

[4] The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis [J].

Cipriani, Sabrina ;

Mencarelli, Andrea ;

Chini, Maria Giovanna ;

Distrutti, Eleonora ;

Renga, Barbara ;

Bifulco, Giuseppe ;

Baldelli, Franco ;

Donini, Annibale ;

Fiorucci, Stefano .

PLOS ONE, 2011, 6 (10)

[5]

Devlin AS, 2015, NAT CHEM BIOL, V11, P685, DOI [10.1038/NCHEMBIO.1864, 10.1038/nchembio.1864]

[6] Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases [J].

Duboc, Henri ;

Rajca, Sylvie ;

Rainteau, Dominique ;

Benarous, David ;

Maubert, Marie-Anne ;

Quervain, Elodie ;

Thomas, Ginette ;

Barbu, Veronique ;

Humbert, Lydie ;

Despras, Guillaume ;

Bridonneau, Chantal ;

Dumetz, Fabien ;

Grill, Jean-Pierre ;

Masliah, Joelle ;

Beaugerie, Laurent ;

Cosnes, Jacques ;

Chazouilleres, Olivier ;

Poupon, Raoul ;

Wolf, Claude ;

Mallet, Jean-Maurice ;

Langella, Philippe ;

Trugnan, Germain ;

Sokol, Harry ;

Seksik, Philippe .

GUT, 2013, 62 (04) :531-539

[7] Co-occurrence of gut microbiota dysbiosis and bile acid metabolism alteration is associated with psychological disorders in Crohn's disease [J].

Feng, Lijuan ;

Zhou, Nan ;

Li, Zichun ;

Fu, Dongni ;

Guo, Ying ;

Gao, Xuefeng ;

Liu, Xiaowei .

FASEB JOURNAL, 2022, 36 (01)

[8] Bile Acids Activated Receptors Regulate innate immunity [J].

Fiorucci, Stefano ;

Biagioli, Michele ;

Zampella, Angela ;

Distrutti, Eleonora .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[9] Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease [J].

Gadaleta, Raffaella M. ;

van Erpecum, Karel J. ;

Oldenburg, Bas ;

Willemsen, Ellen C. L. ;

Renooij, Willem ;

Murzilli, Stefania ;

Klomp, Leo W. J. ;

Siersema, Peter D. ;

Schipper, Marguerite E. I. ;

Danese, Silvio ;

Penna, Giuseppe ;

Laverny, Gilles ;

Adorini, Luciano ;

Moschetta, Antonio ;

van Mil, Saskia W. C. .

GUT, 2011, 60 (04) :463-472

[10] Metabolism of Cholesterol and Bile Acids by the Gut Microbiota [J].

Gerard, Philippe .

PATHOGENS, 2014, 3 (01) :14-24

← 1 2 3 4 5 →