Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

被引：59

作者：

Deenick, Elissa K. ^{[1
,2
]}

Pelham, Simon J. ^{[1
,2
]}

Kane, Alisa ^{[1
,2
,3
,4
]}

Ma, Cindy S. ^{[1
,2
]}

机构：

[1] Garvan Inst Med Res, Div Immunol, Darlinghurst, NSW, Australia

[2] UNSW Sydney, St Vincents Clin Sch, Darlinghurst, NSW, Australia

[3] Liverpool Hosp, Dept Immunol & Allergy, Liverpool, NSW, Australia

[4] UNSW Sydney, South Western Sydney Clin Sch, Liverpool, NSW, Australia

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

基金：

英国医学研究理事会;

关键词：

signal transducer and activator of transcription 3; T cells; B cells; immunodeficiency; immune dysregulation; HYPER-IGE SYNDROME; CHRONIC MUCOCUTANEOUS CANDIDIASIS; INFLAMMATORY-BOWEL-DISEASE; FOLLICULAR-HELPER-CELLS; GENOME-WIDE ASSOCIATION; STAT3; MUTATIONS; ANTIBODY-RESPONSES; PRIMARY IMMUNODEFICIENCIES; HYPERIMMUNOGLOBULIN-E; IL-21; RECEPTOR;

D O I：

10.3389/fimmu.2018.00168

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes. As such, it plays a critical role in regulating B cells as well as CD4(+) and CD8(+) T cells. Patients with clinically significant immunodeficiency and immune dysregulation resulting from loss-of-function or gain-of-function mutations in STAT3 have been described. These individuals provide insight into the critical role of this transcription factor in the regulation of immune responses and the balance between effective immune protection and autoimmunity.

引用

页数：7

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